Copper status of young men consuming a low-copper diet

A study was conducted in 11 young men to evaluate the effect of a low-copper diet on indexes of copper status and to define an amount of dietary copper at which adequate copper status could not be maintained. The young men were confined to a metabolic research unit for 90 d. The study was divided in...

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Bibliographic Details
Published in:The American journal of clinical nutrition 1997-01, Vol.65 (1), p.72-78
Main Authors: Turnlund, JR, Scott, KC, Peiffer, GL, Jang, AM, Keyes, WR, Keen, CL, Sakanashi, TM
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biological and medical sciences
Ceruloplasmin - analysis
Copper
Copper - administration & dosage
Copper - analysis
Copper - blood
Diet
Diet - standards
Humans
Male
Medical research
Medical sciences
Men
Metabolic diseases
Neutrophils - physiology
Nutritional Requirements
Nutritional Status
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Superoxide Dismutase - blood
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Summary:A study was conducted in 11 young men to evaluate the effect of a low-copper diet on indexes of copper status and to define an amount of dietary copper at which adequate copper status could not be maintained. The young men were confined to a metabolic research unit for 90 d. The study was divided into three periods, with dietary copper as the only variable. Dietary copper was 0.66 mg/d for 24 d, 0.38 mg/d for 42 d, and 2.49 mg/d for 24 d. Plasma copper, ceruloplasmin activity, ceruloplasmin concentration, and erythrocyte superoxide dismutase (SOD) were measured at selected time points during each dietary copper period. Urine was collected throughout the study. Plasma copper, ceruloplasmin concentration and activity, and urinary copper declined significantly during the lowest dietary copper period. Plasma copper, ceruloplasmin concentration, and urinary copper increased in response to repletion. The average erythrocyte SOD concentration was lower during the depletion period than in the periods before or after depletion, but it did not decline significantly over time in the depletion period. The results suggest that these indexes are sensitive to copper depletion; that 0.38 mg Cu/d is not sufficient to maintain copper status in normal, healthy young men; and that the minimum dietary copper requirement is between 0.4 and 0.8 mg/d.
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/65.1.72