Intracranial germinoma with Down's syndrome: A case report and review of the literature

Down's syndrome's association with malignancies such as leukemia is well known, but its association with brain tumor appears to be rare. We reviewed such rare cases of Down's syndrome and intracranial germ-cell tumor. A 10-year-old boy with Down's syndrome and intracranial germin...

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Bibliographic Details
Published in:Surgical neurology 1997, Vol.47 (1), p.28-31
Main Authors: Tanabe, Michiharu, Mizushima, Minoru, Anno, Yuichi, Kondou, Shinji, Dejima, Sunao, Hirao, D.Jun, Kamitani, Hideki, Watanabe, Takashi, Hori, Tomokatsu
Format: Article
Language:English
Subjects:
basal ganglia
Basal Ganglia - pathology
Brain Neoplasms - complications
Brain Neoplasms - pathology
brain tumor
Child
Down Syndrome - complications
Down Syndrome - pathology
Down's syndrome
germ-cell tumor
germinoma
Germinoma - complications
Germinoma - pathology
Humans
Male
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Description
Summary:Down's syndrome's association with malignancies such as leukemia is well known, but its association with brain tumor appears to be rare. We reviewed such rare cases of Down's syndrome and intracranial germ-cell tumor. A 10-year-old boy with Down's syndrome and intracranial germinoma located in the left basal ganglia is reported. The patient presented with right hemiparesis and was treated with a combination of surgery, chemotherapy with cisplatin and etoposide, and irradiation. We speculate that the percentage of germ-cell tumors is high among Down syndrome patients with brain tumors and that the most common site is the basal ganglia.
ISSN:0090-3019
1879-3339
DOI:10.1016/S0090-3019(96)00152-8