The impact of intraoperative brachytherapy on surgery of Ewing's sarcoma

Surgery of Ewing's sarcoma sometimes results in an inadequate surgical margin. The influence of intraoperative brachytherapy on local control of the tumor, operation time, blood loss, and surgical complications was evaluated, comparing the results of 20 patients who received brachytherapy to a...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1997, Vol.123 (1), p.53-56
Main Authors: OZAKI, T, HILLMANN, A, RÜBE, C, RÖDL, R, HEIN, M, HOFFMANN, C, BLASIUS, S, JÜRGENS, H, WINKELMANN, W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Bone Neoplasms - radiotherapy
Bone Neoplasms - surgery
Brachytherapy
Child
Combined Modality Therapy
Diseases of the osteoarticular system
Female
Follow-Up Studies
Humans
Intraoperative Period
Male
Medical sciences
Postoperative Complications
Sarcoma, Ewing - radiotherapy
Sarcoma, Ewing - surgery
Tumors of striated muscle and skeleton
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Summary:Surgery of Ewing's sarcoma sometimes results in an inadequate surgical margin. The influence of intraoperative brachytherapy on local control of the tumor, operation time, blood loss, and surgical complications was evaluated, comparing the results of 20 patients who received brachytherapy to a series of 42 patients receiving surgery without brachytherapy. The dose of intraoperative brachytherapy ranged between 9 Gy and 21 Gy. The average operation time was longer in 20 cases with brachytherapy (7.9 h) than in 42 cases without brachytherapy (4.3 h) (P < 0.0001). The average blood loss in the groups with (3531 ml) and without brachytherapy (3515 ml) was comparable (P = 0.3840). The surgical complication rate in patients receiving brachytherapy was also similar to that of untreated patients (30% versus 31%, P = 0.7690). Local relapse developed in 1 of 20 patients who received brachytherapy and 1 of 42 patients without brachytherapy. On the basis of this analysis, it can be concluded that this procedure is safe and does not increase of the acute complication rate. The latest results of local controls are awaited.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF01212615