Genetic analysis of axon guidance and mapping in the zebrafish

Systematic genetic screens have been powerful tools in identifying genes responsible for axon guidance in fruitflies and nematodes. This approach has now been extended to the study of axon guidance and the formation of topographic neuronal connections in the vertebrate brain. A systematic genetic sc...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 1997, Vol.20 (1), p.3-8
Main Authors: Karlstrom, Rolf O., Trowe, Torsten, Bonhoeffer, Friedrich
Format: Article
Language:English
Subjects:
Animals
Axons - physiology
Biological and medical sciences
Danio rerio
Eye and associated structures. Visual pathways and centers. Vision
Fish
Freshwater
Fundamental and applied biological sciences. Psychology
Genetics
Mutation - physiology
Nervous System - cytology
Nervous System - embryology
Neurology
Vertebrates: nervous system and sense organs
Zebrafish - genetics
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Summary:Systematic genetic screens have been powerful tools in identifying genes responsible for axon guidance in fruitflies and nematodes. This approach has now been extended to the study of axon guidance and the formation of topographic neuronal connections in the vertebrate brain. A systematic genetic screen was used to identify genes responsible for precise axon pathfinding and targeting in the retinotectal system of the zebrafish ( Danio rerio). Over 30 genes were found that affect either: (1) retinal axon pathfinding to the contralateral tectal lobe; or (2) the topographic connection between the eye and the tectum. The zebrafish retinotectal mutants represent a new resource for the study of axon guidance in the vertebrate brain.
ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(96)40005-4