Generation of Nitrate During Dialysis as a Measure of Nitric Oxide Synthesis

: Nitric oxide (NO) is a recently identified mes senger, which influences the local regulation of blood flow and platelets as well as neuronal and inflammatory pathways. Disturbed NO information might be involved in the uremic syndrome and might also cause hypotension during dialysis. To clarify the...

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Bibliographic Details
Published in:Artificial organs 1997-02, Vol.21 (2), p.163-167
Main Authors: Mårtensson, Lena, Hegbrant, Jörgen, Thysell, Hans
Format: Article
Language:English
Subjects:
Aged
Blood Pressure - physiology
Complement C3a - metabolism
Creatinine - blood
Female
Gas Chromatography-Mass Spectrometry
Heart Rate - physiology
Hemodialysis
Humans
Male
Middle Aged
Nitrate
Nitrates - blood
Nitrates - metabolism
Nitric oxide
Nitric Oxide - biosynthesis
Phosphates - blood
Radioimmunoassay
Renal Dialysis
Urea - blood
Vasodilation
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Summary:: Nitric oxide (NO) is a recently identified mes senger, which influences the local regulation of blood flow and platelets as well as neuronal and inflammatory pathways. Disturbed NO information might be involved in the uremic syndrome and might also cause hypotension during dialysis. To clarify these issues, we analyzed plasma and dialysis fluid concentrations of nitrate, the stable NO metabolite, in 9 patients during hemodialysis. Plasma nitrate was raised at the onset of dialysis as compared with healthy subjects (83 ± 9 versus 26 ± 2 μ, mol/L). The plasma concentration decreased to 20 ± 2 μ, mol/L (p < 0.01) during the dialysis. The relative decrease was more pronounced than the relative reduction in creatinine, phosphate, and urea concentrations. A parallel decrease in nitrate was seen in effluent dialysis fluid (32 ± 4 to 14 ± 1 μ mol/L; p < 0.01). Calculations of the amount of nitrate coming to and from the dialyzer were performed in 7 of the 9 patients, and in 5 of the 7 patients, generation of nitrate within the dialyzer could be postulated. This might explain the paradoxical venodilation noted during hemodialysis.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.1997.tb00355.x