Lesion of the Area Postrema Region Attenuates Hypertension in Spontaneously Hypertensive Rats

To determine whether the area postrema contributes to the development of hypertension in spontaneously hypertensive rats (SHR), sham or electrolytic lesions of the area postrema (AP) were made in 4-week-old SHR and Wistar-Kyoto (WKY) controls. From weeks 5 through 16, systolic pressure was measured...

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Bibliographic Details
Published in:Circulation research 1989-01, Vol.64 (1), p.129-135
Main Authors: Mangiapane, Michael L, Skoog, Kathleen M, Rittenhouse, Peter, Blair, Martha L, Sladek, Celia D
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Cerebral Ventricles - pathology
Cerebral Ventricles - physiopathology
Experimental diseases
Heart Rate
Hypertension - physiopathology
Male
Medical sciences
Medulla Oblongata - pathology
Pressoreceptors - physiology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Systole
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Summary:To determine whether the area postrema contributes to the development of hypertension in spontaneously hypertensive rats (SHR), sham or electrolytic lesions of the area postrema (AP) were made in 4-week-old SHR and Wistar-Kyoto (WKY) controls. From weeks 5 through 16, systolic pressure was measured via tail plethysmography. While blood pressure rose markedly in sham-operated SHR, increases in pressure were small in AP-ablated SHR and similar to those seen in all WKY. Subsequent direct measurements of mean arterial pressure in the same rats showed a significant correlation (r=0.87, p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.64.1.129