Structural and functional development of outer versus inner cortical proximal tubules

The concept of centrifugal renal development is based on renal embryogenesis. It implies a relationship between nephron age and nephron position along a cortical to medullary axis. In common usage, however, it often also implies a relationship between nephron age or position and nephron maturity. We...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1988-01, Vol.2 (1), p.108-114
Main Authors: Welling, L W, Linshaw, M A
Format: Article
Language:English
Subjects:
Animals
Cell Membrane - ultrastructure
Humans
Juxtaglomerular Apparatus - embryology
Juxtaglomerular Apparatus - growth & development
Kidney Cortex - embryology
Kidney Cortex - growth & development
Kidney Medulla - embryology
Kidney Medulla - growth & development
Kidney Tubules, Proximal - embryology
Kidney Tubules, Proximal - growth & development
Kidney Tubules, Proximal - physiology
Rabbits
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Summary:The concept of centrifugal renal development is based on renal embryogenesis. It implies a relationship between nephron age and nephron position along a cortical to medullary axis. In common usage, however, it often also implies a relationship between nephron age or position and nephron maturity. We consider here whether the ideas of centrifugal development and centrifugal maturation should in fact be considered as separate and distinct concepts. That is, we consider the possibility that nephron maturity does not necessarily correlate with nephron age. Unfortunately, pertinent reported data give no clear answer. We conclude only that further study will be required before definitive conclusions about renal developmental stages can be stated with certainty.
ISSN:0931-041X
1432-198X
DOI:10.1007/BF00870389