Sonodynamically induced antitumor effect of gallium-porphyrin complex by focused ultrasound on experimental kidney tumor

The antitumor effect of a gallium-porphyrin complex, ATX-70, induced by focused ultrasound, on colon 26 carcinoma implanted in a mouse kidney was investigated. Colon 26 tumors were exposed to focused ultrasound at 500 kHz and 1 MHz in a progressive wave mode. Both frequency components were superimpo...

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Bibliographic Details
Published in:Cancer letters 1997-01, Vol.112 (1), p.79-86
Main Authors: Yumita, Nagahiko, Sasaki, Kazuaki, Umemura, Shin-ichiro, Yukawa, Atsuo, Nishigaki, Ryuichiro
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Antitumor effect
Biological and medical sciences
Colon 26
Combined Modality Therapy
Focused ultrasound
Kidney
Male
Medical sciences
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms - drug therapy
Neoplasms - therapy
Other treatments
Porphyrin complex
Porphyrins - therapeutic use
Sonodynamic therapy
Treatment. General aspects
Tumors
Ultrasonic Therapy - methods
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Summary:The antitumor effect of a gallium-porphyrin complex, ATX-70, induced by focused ultrasound, on colon 26 carcinoma implanted in a mouse kidney was investigated. Colon 26 tumors were exposed to focused ultrasound at 500 kHz and 1 MHz in a progressive wave mode. Both frequency components were superimposed onto each other in the focal zone to efficiently produce cavitation in the tumor. ATX-70 was administered intravenously at the dose of 2.5 mg/kg, 24 h before the ultrasonic exposure. Antitumor effects were evaluated by histological observation 7 days after the exposure. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with ATX-70, while neither the treatment with ATX-70 alone nor that with ultrasound alone caused any necrosis. These results first demonstrated that antitumor effects of a porphyrin compound can be induced by focused ultrasound in a progressive wave mode.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(96)04548-X