Sonodynamically induced antitumor effect of gallium-porphyrin complex by focused ultrasound on experimental kidney tumor

• Published in: Cancer letters 1997-01, Vol.112 (1), p.79-86
• Main Authors: Yumita, Nagahiko, Sasaki, Kazuaki, Umemura, Shin-ichiro, Yukawa, Atsuo, Nishigaki, Ryuichiro
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Antitumor effect; Biological and medical sciences; Colon 26; Combined Modality Therapy; Focused ultrasound; Kidney; Male; Medical sciences; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms - drug therapy; Neoplasms - therapy; Other treatments; Porphyrin complex; Porphyrins - therapeutic use; Sonodynamic therapy; Treatment. General aspects; Tumors; Ultrasonic Therapy - methods
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(96)04548-X

The antitumor effect of a gallium-porphyrin complex, ATX-70, induced by focused ultrasound, on colon 26 carcinoma implanted in a mouse kidney was investigated. Colon 26 tumors were exposed to focused ultrasound at 500 kHz and 1 MHz in a progressive wave mode. Both frequency components were superimposed onto each other in the focal zone to efficiently produce cavitation in the tumor. ATX-70 was administered intravenously at the dose of 2.5 mg/kg, 24 h before the ultrasonic exposure. Antitumor effects were evaluated by histological observation 7 days after the exposure. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with ATX-70, while neither the treatment with ATX-70 alone nor that with ultrasound alone caused any necrosis. These results first demonstrated that antitumor effects of a porphyrin compound can be induced by focused ultrasound in a progressive wave mode.