Metabolic myocardial viability assessment with iodine 123-16-iodo-3-methylhexadecanoic acid in recent myocardial infarction : comparison with thallium-201 and fluorine-18 fluorodeoxyglucose

The best test presently available to ascertain residual viability within an infarct-related area involves the use of fluorine-18 fluorodeoxyglucose (FDG) to detect the persistence of some cellular metabolism. Rest reinjection of thallium-201 is a less accurate alternative but is easy to perform. Iod...

Full description

Saved in:
Bibliographic Details
Published in:European Journal of Nuclear Medicine 1997-02, Vol.24 (2), p.170-178
Main Authors: VANZETTO, G, JANIER, M, FAGRET, D, CINOTTI, L, ANDRE-FOUET, X, COMET, M, MACHECOURT, J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular system
Contrast media. Radiopharmaceuticals
Deoxyglucose - analogs & derivatives
Exercise Test
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Heart - diagnostic imaging
Humans
Investigative techniques, diagnostic techniques (general aspects)
Iodine Radioisotopes
Medical sciences
Middle Aged
Myocardial Infarction - diagnostic imaging
Palmitic Acids
Pharmacology. Drug treatments
Predictive Value of Tests
Radionuclide investigations
ROC Curve
Sensitivity and Specificity
Thallium Radioisotopes
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The best test presently available to ascertain residual viability within an infarct-related area involves the use of fluorine-18 fluorodeoxyglucose (FDG) to detect the persistence of some cellular metabolism. Rest reinjection of thallium-201 is a less accurate alternative but is easy to perform. Iodinated fatty acids, which are used with standard gamma cameras, are proposed as markers of cellular metabolism. This study was performed to assess the value of 16-iodo-3-methylhexadecanoic acid (MIHA) as a marker of the residual cellular metabolism by comparison with FDG in patients with a recent myocardial infarction, and to evaluate its contribution compared with the 201Tl stress-redistribution-reinjection technique. Stress-redistribution-reinjection 201Tl imaging, rest MIHA imaging and glucose-loaded FDG imaging were performed in 22 patients with recent myocardial infarction. Out of the 628 myocardial segments obtained from the left ventricular analysis, 400 were hypoperfused (relative uptake
ISSN:0340-6997
1619-7089
DOI:10.1007/BF02439549