Enhanced epithelial proliferation due to elevated levels of interleukin-1 receptors in middle ear cholesteatomas

Middle ear cholesteatoma epithelium is a rich source of interleukin-1-alpha (IL-1-alpha), being involved in both keratinocyte hyperproliferation and bone destruction. IL-1-alpha exerts its effects by binding to two distinct IL-1 receptors (IL-1-R). In this study, we have examined the expression of I...

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Published in:European archives of oto-rhino-laryngology 1997-01, Vol.254 (1), p.6-8
Main Authors: BUJIA, J, KIM, C, OSTOS-AUMENTE, P, LOPEZ-VILLAREJO, J, KASTENBAUER, E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Division - physiology
Cholesteatoma, Middle Ear - pathology
Cholesteatoma, Middle Ear - surgery
Ear Canal - pathology
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Epithelium - pathology
Humans
Image Processing, Computer-Assisted
Immunoenzyme Techniques
Medical sciences
Otorhinolaryngology. Stomatology
Receptors, Interleukin-1 - analysis
Receptors, Interleukin-1 - physiology
Tumors
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Summary:Middle ear cholesteatoma epithelium is a rich source of interleukin-1-alpha (IL-1-alpha), being involved in both keratinocyte hyperproliferation and bone destruction. IL-1-alpha exerts its effects by binding to two distinct IL-1 receptors (IL-1-R). In this study, we have examined the expression of IL-1-R type II (IL-1-R-II) in cholesteatoma samples and have quantified these levels with computer-assisted image analysis. Normal aural skin was used as control. Immunostaining demonstrated the presence of IL-1-R-II in both epidermis and cholesteatoma keratinocytes. The receptors were 3 times higher than those in normal epidermis. The presence of IL-1-alpha in cholesteatoma epithelium coupled with the induced expression of IL-1-R-II indicates the existence of a highly regulated system of autocrine stimulation of cholesteatoma keratinocytes by IL-1.
ISSN:0937-4477
1434-4726
DOI:10.1007/BF02630748