Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide

• Published in: Journal of applied physiology (1985) 1997-01, Vol.82 (1), p.111-117
• Main Authors: Albert, T. S. E, Tucker, V. L, Renkin, E. M
• Format: Article
• Language: English
• Subjects: Albumins - metabolism; Albumins - physiology; Animals; Apud cells. Peptide and protein hormones. Growth factors; Atrial Natriuretic Factor - metabolism; Biological and medical sciences; Biological Transport; Fundamental and applied biological sciences. Psychology; Hypoxia - metabolism; Hypoxia - physiopathology; Male; Pulmonary Alveoli - metabolism; Rats; Rats, Wistar; Time Factors; Vertebrates: endocrinology
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1997.82.1.111

T. S. E. Albert, V. L. Tucker, and E. M. Renkin Department of Human Physiology, University of California, Davis, California 95616 Received 1 February 1996; accepted in final form 4 September 1996. Albert, T. S. E., V. L. Tucker, and E. M. Renkin. Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide. J. Appl. Physiol. 82(1): 111-117, 1997. Plasma immunoreactive atrial natriuretic peptide (irANP) and blood-to-tissue clearance of 131 I-labeled rat serum albumin (C RSA ) were examined in anesthetized rats during hypoxic ventilation ( n  = 5-7/group). Hypoxia (10 min) increased irANP from 211 ± 29 (room air) to 229 ± 28 (15% O 2 , not significant), 911 ± 205 (10% O 2 ), and 4,374 ± 961 pg/ml (8% O 2 ), respectively. Graded increases in C RSA were significant at 8% O 2 in fat (3.6-fold), ileum (2.2-fold), abdominal muscles (2.0-fold), kidney (1.8-fold), and jejunum (1.4-fold). C RSA was decreased in back skin and testes; heart, brain, and lungs were unaffected. The increases in C RSA were related to irANP and not to arterial P O 2 . Circulating plasma volume was negatively correlated with whole body C RSA . Graded increases in extravascular water content (EVW) were found in the kidney, left heart, and cerebrum and were positively related to C RSA in the kidney. EVW decreased in gastrointestinal tissues; the magnitude was inversely related to C RSA . We conclude that ANP-induced protein extravasation contributes to plasma volume contraction during acute hypoxia. plasma volume; capillary permeability; albumin clearance; edema 0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society