A Mammalian Telomerase-Associated Protein

The telomerase ribonucleoprotein catalyzes the addition of new telomeres onto chromosome ends. A gene encoding a mammalian telomerase homolog called TP1 (telomerase-associated protein 1) was identified and cloned. TP1 exhibited extensive amino acid similarity to the Tetrahymena telomerase protein p8...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1997-02, Vol.275 (5302), p.973-977
Main Authors: Harrington, Lea, McPhail, Timothy, Mar, Vernon, Zhou, Wen, Oulton, Rena, Program, Amgen EST, Bass, Mike B., Arruda, Isabel, Robinson, Murray O.
Format: Article
Language:English
Subjects:
3T3 cells
Amino Acid Sequence
Amino acids
Animals
Antibodies
Biological and medical sciences
Blotting, Northern
Carrier Proteins - chemistry
Carrier Proteins - genetics
Carrier Proteins - immunology
Carrier Proteins - metabolism
Cell Line
Cell lines
Cellular immunity
Chromatin. Chromosome
Cloning, Molecular
DNA, Complementary - genetics
Fundamental and applied biological sciences. Psychology
Genes
Humans
Libraries
Literary Devices
Mammals
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
NIH 3T3 cells
Nucleoproteins
Precipitin Tests
Proteins
Ribonucleic acid
RNA
RNA - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sequence Homology, Amino Acid
Telomerase - chemistry
Telomerase - genetics
Telomerase - metabolism
Telomeres
Tetrahymena - chemistry
Tetrahymena - genetics
Transcripts (Written Records)
Transfection
Tumor Cells, Cultured
Yeasts
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Description
Summary:The telomerase ribonucleoprotein catalyzes the addition of new telomeres onto chromosome ends. A gene encoding a mammalian telomerase homolog called TP1 (telomerase-associated protein 1) was identified and cloned. TP1 exhibited extensive amino acid similarity to the Tetrahymena telomerase protein p80 and was shown to interact specifically with mammalian telomerase RNA. Antiserum to TP1 immunoprecipitated telomerase activity from cell extracts, suggesting that TP1 is associated with telomerase in vivo. The identification of TP1 suggests that telomerase-associated proteins are conserved from ciliates to humans.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.275.5302.973