Tetramethylpyrazine for treatment of experimentally induced stroke in Mongolian gerbils

Tetramethylpyrazine, a drug originally isolated from the rhizome of Ligusticum walliichi, has been used routinely in China for the treatment of stroke and angina pectoris. We evaluated this drug by testing its effectiveness in increasing the survival rate in a stroke model using Mongolian gerbils. O...

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Bibliographic Details
Published in:Stroke (1970) 1989, Vol.20 (1), p.96-99
Main Authors: HO, W. K. K, HSIANG LAI WEN, CHI MING LEE
Format: Article
Language:English
Subjects:
Animals
Binding, Competitive
Biological and medical sciences
Brain - pathology
Brain Ischemia - physiopathology
Cardiovascular system
Cerebrovascular Disorders - drug therapy
Cerebrovascular Disorders - mortality
Cerebrovascular Disorders - pathology
Gerbillinae
Male
Medical sciences
Pharmacology. Drug treatments
Pyrazines - pharmacokinetics
Pyrazines - therapeutic use
Vasodilator agents. Cerebral vasodilators
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Summary:Tetramethylpyrazine, a drug originally isolated from the rhizome of Ligusticum walliichi, has been used routinely in China for the treatment of stroke and angina pectoris. We evaluated this drug by testing its effectiveness in increasing the survival rate in a stroke model using Mongolian gerbils. Our results indicate that tetramethylpyrazine can increase survival rate only if it is administered before the induction of cerebral ischemia. Since we administered the drug intraperitoneally, it is possible that pretreatment was necessary to increase its effective concentration in the blood. Receptor binding studies indicated that tetramethylpyrazine was inactive against a variety of pharmacologically active receptors.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.20.1.96