Inhibition of Hemopoietic Colony Formation by Human Cytomegalovirus in Vitro

Transient neutropenia and thrombocytopenia may occur in the course of acute human cytomegalovirus (HCMV) infections, particularly in immunocompromised patients, newborn infants, and congenitally infected infants. The authors examined the effect of HCMV on hemopoietic cell colony formation in vitro....

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Bibliographic Details
Published in:The Journal of infectious diseases 1989-01, Vol.159 (1), p.127-130
Main Authors: Rakusan, Tamara A., Juneja, Harinder S., Fleischmann, W. Robert
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone marrow
Bone Marrow Cells
Cell Division
Cells, Cultured
Concise Communications
Cytomegalovirus
Cytomegalovirus - physiology
Erythropoiesis
Female
Fetal Blood - cytology
Fibroblasts
Fundamental and applied biological sciences. Psychology
Grants
Granulocytes - cytology
Hematopoiesis
Humans
Infant, Newborn
Infants
Infections
Interferons
Leukocytes, Mononuclear - microbiology
Macrophages - cytology
Microbiology
Monocytes
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Virology
Viruses
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Summary:Transient neutropenia and thrombocytopenia may occur in the course of acute human cytomegalovirus (HCMV) infections, particularly in immunocompromised patients, newborn infants, and congenitally infected infants. The authors examined the effect of HCMV on hemopoietic cell colony formation in vitro. Mononuclear cells (MNCs) isolated from normal human bone marrow (BM) or from cord blood (CB) from normal deliveries were infected with either a laboratory strain or one of several recent clinical isolates of HCMV, and the formation of granulocyte/macrophage (GM) or erythrocytic (BFU-E) colonies in semi-solid medium was measured.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/159.1.127