Induction of psoriasiform inflammation by a bacterial superantigen in the SCID-hu xenogeneic transplantation model

Psoriasis is a chronic skin disease affecting about 2% of the Caucasian population, characterized by co‐existing inflammation and epidermal hyperproliferation. A T‐lymphocyte‐mediated autoimmune reaction induced by bacterial superantigens might be central in its pathogenesis. To model psoriasiform i...

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Bibliographic Details
Published in:Journal of cutaneous pathology 1997-01, Vol.24 (1), p.1-7
Main Authors: Boehncke, Wolf-Henning, Zollner, Thomas Matthias, Dressel, Daniela, Kaufmann, Roland
Format: Article
Language:English
Subjects:
Animals
Antigens, Differentiation, T-Lymphocyte
Antigens, Neoplasm
Bacteria
Bacterial Toxins - pharmacology
Biological and medical sciences
CD3 Complex - analysis
Dermatology
Exocytosis - immunology
Female
Humans
Immunophenotyping
Injections, Intradermal
Leukocytes, Mononuclear - transplantation
Male
Medical sciences
Membrane Glycoproteins - biosynthesis
Mice
Mice, SCID
Psoriasis - etiology
Psoriasis - immunology
Psoriasis - pathology
Psoriasis. Parapsoriasis. Lichen
Skin Transplantation - immunology
Skin Transplantation - pathology
Staphylococcus aureus - immunology
Superantigens - administration & dosage
Superantigens - immunology
T-Lymphocytes - immunology
T-Lymphocytes - pathology
Transplantation, Heterologous - immunology
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Summary:Psoriasis is a chronic skin disease affecting about 2% of the Caucasian population, characterized by co‐existing inflammation and epidermal hyperproliferation. A T‐lymphocyte‐mediated autoimmune reaction induced by bacterial superantigens might be central in its pathogenesis. To model psoriasiform inflammation, we transplanted clinically uninvolved skin from psoriatic patients onto SCID mice. Repetitive intradermal injections with a bacterial superantigen and simultaneous intraperitoneal injections with the patients' superantigen‐stimulated peripheral mononuclear blood cells resulted in an inflammatory reaction exhibiting some of the hallmarks of psoriasis, e.g. epidermal hy‐perproliferation, papillomatosis, focal neo‐expression of ICAM‐1, and an exocytotic T‐lymphocytic infiltrate characterized by the expression of the cutaneous lymphocyte‐associated antigen. These observations document the potential of superantigens to trigger psoriasiform dermatitis and provide a model to study lymphocyte homing.
ISSN:0303-6987
1600-0560
DOI:10.1111/j.1600-0560.1997.tb00778.x