Increased Expression of Cardiac Phosphatases in Patients with End-stage Heart Failure

Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 1997-01, Vol.29 (1), p.265-272
Main Authors: Neumann, Joachim, Eschenhagen, Thomas, Jones, Larry R., Linck, Bettina, Schmitz, Wilhelm, Scholz, Hasso, Zimmermann, Norbert
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
Adult
Animals
Blotting, Northern
Cardiomyopathy, Dilated - metabolism
Case-Control Studies
Female
Gene Expression Regulation, Enzymologic - physiology
Heart Ventricles - metabolism
Human heart failure
Humans
Male
Membranes - metabolism
Middle Aged
Phosphatases
Phosphoric Monoester Hydrolases - genetics
Protein phosphorylation
Rats
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Summary:Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.
ISSN:0022-2828
1095-8584
DOI:10.1006/jmcc.1996.0271