Innovative Approaches to Plasminogen Activator Therapy

Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of molecular biology and protein engineering are being used to develop safer an...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1989-01, Vol.243 (4887), p.51-56
Main Authors: Haber, Edgar, Quertermous, Thomas, Matsueda, Gary R., Runge, Marschall S.
Format: Article
Language:English
Subjects:
Antibodies
Biochemistry
Biological and medical sciences
Cardiovascular disease
cardiovascular pathology
Cardiovascular system
Catalytic activity
Clotting
Disulfides
Drugs
Exons
Fibrinolytic agents
genetic engineering
genetics
Health care
Humans
Low molecular weights
Medical research
Medical sciences
Miscellaneous
Molecules
myocardial infarction
Myocardial Infarction - drug therapy
Pharmacology. Drug treatments
plasminogen activator
Plasminogen activators
Plasminogen Activators - therapeutic use
Plasminogen inactivators
Protein Conformation
Proteins
Recombinant Proteins - therapeutic use
Streptokinase - therapeutic use
Thrombolytic drugs
Thrombosis
Tissue plasminogen activator
Tissue Plasminogen Activator - therapeutic use
Urokinase-Type Plasminogen Activator - therapeutic use
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Summary:Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of molecular biology and protein engineering are being used to develop safer and more effective plasminogen activators.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2492113