Importance of Venodilatation in Prevention of Left Ventricular Dilatation After Chronic Large Myocardial Infarction in Rats: A Comparison of Captopril and Hydralazine

In rats with large myocardial infarctions, we compared the effects of captopril, a presumed arterial and venous vasodilator, with hydralazine, which is thought primarily to be an arterial vasodilator. To determine if the effects of captopril were dependent on the pathophysiological consequences of h...

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Bibliographic Details
Published in:Circulation research 1989-02, Vol.64 (2), p.330-337
Main Authors: Raya, Thomas E, Gay, Richard G, Aguirre, Maria, Goldman, Steven
Format: Article
Language:English
Subjects:
Animals
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Blood Volume - drug effects
Captopril - pharmacology
Cardiovascular system
Chronic Disease
Heart - drug effects
Heart - physiopathology
Heart Ventricles
Hydralazine - pharmacology
Male
Medical sciences
Myocardial Infarction - physiopathology
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Stroke Volume - drug effects
Vasodilator Agents - pharmacology
Vasodilator Agents - therapeutic use
Veins - drug effects
Veins - physiopathology
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Summary:In rats with large myocardial infarctions, we compared the effects of captopril, a presumed arterial and venous vasodilator, with hydralazine, which is thought primarily to be an arterial vasodilator. To determine if the effects of captopril were dependent on the pathophysiological consequences of heart failure, we also studied a group of noninfarcted rats treated with captopril. In noninfarcted rats treated with captopril, left ventricular (LV) systolic and mean aortic pressures decreased from 132±12 to 107±15 mm Hg and 122±1 to 100±2, respectively (p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.64.2.330