The concentration of sodium,potassium pumps in chronic obstructive lung disease (COLD) patients: the impact of magnesium depletion and steroid treatment

• Published in: Journal of internal medicine 1997-01, Vol.241 (1), p.23-29
• Main Authors: RAVN, H. B., DØRUP, I.
• Format: Article
• Language: English
• Subjects: [3H]ouabain binding sites; Animals; Biological and medical sciences; Biopsy; Case-Control Studies; Cross-Sectional Studies; diuretics; Female; Glucocorticoids - pharmacology; Glucocorticoids - therapeutic use; Humans; Lung Diseases, Obstructive - blood; Lung Diseases, Obstructive - drug therapy; Lung Diseases, Obstructive - metabolism; magnesium; Magnesium - blood; Magnesium - metabolism; Male; Medical sciences; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Na‐K‐ATPase; Pharmacology. Drug treatments; potassium; Rats; Respiratory system; Sodium-Potassium-Exchanging ATPase - blood; Sodium-Potassium-Exchanging ATPase - drug effects; Sodium-Potassium-Exchanging ATPase - metabolism; β2‐agonists
• ISSN: 0954-6820; 1365-2796
• DOI: 10.1046/j.1365-2796.1997.69891000.x

Objectives. To evaluate the concentrations of magnesium (Mg), potassium (K) and sodium,potassium pumps (Na,K pumps) in skeletal muscle in patients with chronic obstructive lung disease (COLD) treated with or without diuretics. Design. An open cross‐sectional study. Setting. COLD patients admitted to the Medical Department of Vejle Hospital, Denmark. Subjects. Thirty‐six consecutive COLD patients and 23 age‐ and sex‐matched controls. Main outcome measures. Biopsies of skeletal muscle were performed in patients and controls for measurements of Mg, K and Na,K pumps. In a parallel animal experiment the influence of medical treatment on the concentration of Na,K pumps in skeletal muscle was evaluated by infusing 10‐week‐old rats for 14 days with vehicle, terbutaline, or dexamethasone. Results.In the patients, mean muscle Mg and K concentrations were reduced by 22 and 14%, respectively (P