Serum levels of soluble CD44 variant isoforms are elevated in rheumatoid arthritis

Serum levels of soluble CD44 variant proteins including sequences encoded by exon v5 and exon v6 (sCD44v5, sCD44v6) were determined in patients with inflammatory rheumatic diseases: 56 with rheumatoid arthritis (RA+) and 31 with miscellaneous inflammatory rheumatic diseases (MIRD). There were very s...

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Bibliographic Details
Published in:Rheumatology international 1997-01, Vol.16 (5), p.181-186
Main Authors: KITTL, E. M, HABERHAUER, G, RUCKSER, R, SELLENY, S, RECH-WEICHSELBRAUN, I, HINTERBERGER, W, BAUER, K
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibodies, Antinuclear - immunology
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
Biological and medical sciences
Blood Cell Count
Blood Sedimentation
C-Reactive Protein - metabolism
Diseases of the osteoarticular system
Drug therapy
Enzyme-Linked Immunosorbent Assay
Female
Hemoglobins - metabolism
Humans
Hyaluronan Receptors - blood
Immunoglobulin M - immunology
Immunosuppressive Agents - therapeutic use
Inflammatory joint diseases
Male
Medical sciences
Middle Aged
Rheumatic diseases
Rheumatoid arthritis
Rheumatoid Factor - immunology
Treatment Outcome
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Summary:Serum levels of soluble CD44 variant proteins including sequences encoded by exon v5 and exon v6 (sCD44v5, sCD44v6) were determined in patients with inflammatory rheumatic diseases: 56 with rheumatoid arthritis (RA+) and 31 with miscellaneous inflammatory rheumatic diseases (MIRD). There were very significantly higher serum levels of sCD44v5 and sCD44v6 in patients with RA+ than in those with MIRD (RA+ to MIRD: sCD44v5: 81 +/- 54 ng/ml to 33 +/- 13 ng/ml; sCD44v6: 237 +/- 124 ng/ml to 166 +/- 53 ng/ml; both P
ISSN:0172-8172
1437-160X
DOI:10.1007/BF01330293