Loading…

Methylprednisolone in spinal cord compression

In acute nonsurvival studies, eight anesthetized lambs were subjected to cord compression at T13 by means of an epidural balloon distended to a pressure of 200 mm Hg for 40 minutes. Subsequent to withdrawal of the balloon, each animal received 30 mg/kg of methylprednisolone succinate in an intraveno...

Full description

Saved in:

Bibliographic Details
Published in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 1989, Vol.14 (1), p.16-22
Main Authors:	HITCHON, P. W, MCKAY, T. C, WILKONSON, T. T, GIRTON, R. A. III, HANSEN, T, DYSTE, G. N
Format:	Article
Language:	English
Subjects:	Animals Biological and medical sciences Evoked Potentials, Somatosensory - drug effects Female Male Medical sciences Methylprednisolone - analogs & derivatives Methylprednisolone Hemisuccinate - therapeutic use Nervous system involvement in other diseases. Miscellaneous Neurology Regional Blood Flow - drug effects Sheep Spinal Cord - blood supply Spinal Cord Compression - drug therapy Spinal Cord Compression - physiopathology
Citations:	Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c368t-3f1283dcb666b6e7ac767ffac8a91b794655eb042d864b64800649db31bbc4253
cites
container_end_page	22
container_issue	1
container_start_page	16
container_title	Spine (Philadelphia, Pa. 1976)
container_volume	14
creator	HITCHON, P. W MCKAY, T. C WILKONSON, T. T GIRTON, R. A. III HANSEN, T DYSTE, G. N
description	In acute nonsurvival studies, eight anesthetized lambs were subjected to cord compression at T13 by means of an epidural balloon distended to a pressure of 200 mm Hg for 40 minutes. Subsequent to withdrawal of the balloon, each animal received 30 mg/kg of methylprednisolone succinate in an intravenous bolus followed by a continuous infusion of 10 mg/kg/hr for the duration of the experiment. Spinal cord blood flow (SCBF) and spinal evoked potential (SEP) determinations were obtained sequentially prior to, during, and at 1/2, 1 1/2, and 2 1/2 hours following compression. In spite of the absence of ischemia following compression, SEPs failed to recover. Methylprednisolone had no apparent effect on blood flow or on the recovery of SEPs when compared with results in ten control animals that received saline alone.
doi_str_mv	10.1097/00007632-198901000-00004
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78828991</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78828991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-3f1283dcb666b6e7ac767ffac8a91b794655eb042d864b64800649db31bbc4253</originalsourceid><addsrcrecordid>eNo9UMtOAzEMjBColMInIO0BcQvktd7kiCpeUhEXOEdJNiuC9kXSHvr3pHRZH2zZM2Nbg1BByR0lqronOSrgDFMlFaG5w4eROEFLWjKJKS3VKVoSDgwzweEcXaT0nRnAqVqgBQPBJRdLhN_89mvfjtHXfUhDO_S-CH2RxtCbtnBDrHPqMpxSGPpLdNaYNvmrqa7Q59Pjx_oFb96fX9cPG-w4yC3mDWWS184CgAVfGVdB1TTGSaOorZSAsvSWCFZLEBaEzH8JVVtOrXWClXyFbo97xzj87Hza6i4k59vW9H7YJV1JyaRSNBPlkejikFL0jR5j6Ezca0r0wSn975SenfobiSy9nm7sbOfrWThZk_GbCTfJmbaJpnchzTSQqlSK8F-3Gm-V</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78828991</pqid></control><display><type>article</type><title>Methylprednisolone in spinal cord compression</title><source>HEAL-Link subscriptions: Lippincott Williams & Wilkins</source><creator>HITCHON, P. W ; MCKAY, T. C ; WILKONSON, T. T ; GIRTON, R. A. III ; HANSEN, T ; DYSTE, G. N</creator><creatorcontrib>HITCHON, P. W ; MCKAY, T. C ; WILKONSON, T. T ; GIRTON, R. A. III ; HANSEN, T ; DYSTE, G. N</creatorcontrib><description>In acute nonsurvival studies, eight anesthetized lambs were subjected to cord compression at T13 by means of an epidural balloon distended to a pressure of 200 mm Hg for 40 minutes. Subsequent to withdrawal of the balloon, each animal received 30 mg/kg of methylprednisolone succinate in an intravenous bolus followed by a continuous infusion of 10 mg/kg/hr for the duration of the experiment. Spinal cord blood flow (SCBF) and spinal evoked potential (SEP) determinations were obtained sequentially prior to, during, and at 1/2, 1 1/2, and 2 1/2 hours following compression. In spite of the absence of ischemia following compression, SEPs failed to recover. Methylprednisolone had no apparent effect on blood flow or on the recovery of SEPs when compared with results in ten control animals that received saline alone.</description><identifier>ISSN: 0362-2436</identifier><identifier>EISSN: 1528-1159</identifier><identifier>DOI: 10.1097/00007632-198901000-00004</identifier><identifier>PMID: 2643834</identifier><identifier>CODEN: SPINDD</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott</publisher><subject>Animals ; Biological and medical sciences ; Evoked Potentials, Somatosensory - drug effects ; Female ; Male ; Medical sciences ; Methylprednisolone - analogs & derivatives ; Methylprednisolone Hemisuccinate - therapeutic use ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Regional Blood Flow - drug effects ; Sheep ; Spinal Cord - blood supply ; Spinal Cord Compression - drug therapy ; Spinal Cord Compression - physiopathology</subject><ispartof>Spine (Philadelphia, Pa. 1976), 1989, Vol.14 (1), p.16-22</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-3f1283dcb666b6e7ac767ffac8a91b794655eb042d864b64800649db31bbc4253</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6895990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2643834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HITCHON, P. W</creatorcontrib><creatorcontrib>MCKAY, T. C</creatorcontrib><creatorcontrib>WILKONSON, T. T</creatorcontrib><creatorcontrib>GIRTON, R. A. III</creatorcontrib><creatorcontrib>HANSEN, T</creatorcontrib><creatorcontrib>DYSTE, G. N</creatorcontrib><title>Methylprednisolone in spinal cord compression</title><title>Spine (Philadelphia, Pa. 1976)</title><addtitle>Spine (Phila Pa 1976)</addtitle><description>In acute nonsurvival studies, eight anesthetized lambs were subjected to cord compression at T13 by means of an epidural balloon distended to a pressure of 200 mm Hg for 40 minutes. Subsequent to withdrawal of the balloon, each animal received 30 mg/kg of methylprednisolone succinate in an intravenous bolus followed by a continuous infusion of 10 mg/kg/hr for the duration of the experiment. Spinal cord blood flow (SCBF) and spinal evoked potential (SEP) determinations were obtained sequentially prior to, during, and at 1/2, 1 1/2, and 2 1/2 hours following compression. In spite of the absence of ischemia following compression, SEPs failed to recover. Methylprednisolone had no apparent effect on blood flow or on the recovery of SEPs when compared with results in ten control animals that received saline alone.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Evoked Potentials, Somatosensory - drug effects</subject><subject>Female</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylprednisolone - analogs & derivatives</subject><subject>Methylprednisolone Hemisuccinate - therapeutic use</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Regional Blood Flow - drug effects</subject><subject>Sheep</subject><subject>Spinal Cord - blood supply</subject><subject>Spinal Cord Compression - drug therapy</subject><subject>Spinal Cord Compression - physiopathology</subject><issn>0362-2436</issn><issn>1528-1159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNo9UMtOAzEMjBColMInIO0BcQvktd7kiCpeUhEXOEdJNiuC9kXSHvr3pHRZH2zZM2Nbg1BByR0lqronOSrgDFMlFaG5w4eROEFLWjKJKS3VKVoSDgwzweEcXaT0nRnAqVqgBQPBJRdLhN_89mvfjtHXfUhDO_S-CH2RxtCbtnBDrHPqMpxSGPpLdNaYNvmrqa7Q59Pjx_oFb96fX9cPG-w4yC3mDWWS184CgAVfGVdB1TTGSaOorZSAsvSWCFZLEBaEzH8JVVtOrXWClXyFbo97xzj87Hza6i4k59vW9H7YJV1JyaRSNBPlkejikFL0jR5j6Ezca0r0wSn975SenfobiSy9nm7sbOfrWThZk_GbCTfJmbaJpnchzTSQqlSK8F-3Gm-V</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>HITCHON, P. W</creator><creator>MCKAY, T. C</creator><creator>WILKONSON, T. T</creator><creator>GIRTON, R. A. III</creator><creator>HANSEN, T</creator><creator>DYSTE, G. N</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Methylprednisolone in spinal cord compression</title><author>HITCHON, P. W ; MCKAY, T. C ; WILKONSON, T. T ; GIRTON, R. A. III ; HANSEN, T ; DYSTE, G. N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-3f1283dcb666b6e7ac767ffac8a91b794655eb042d864b64800649db31bbc4253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Evoked Potentials, Somatosensory - drug effects</topic><topic>Female</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylprednisolone - analogs & derivatives</topic><topic>Methylprednisolone Hemisuccinate - therapeutic use</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Regional Blood Flow - drug effects</topic><topic>Sheep</topic><topic>Spinal Cord - blood supply</topic><topic>Spinal Cord Compression - drug therapy</topic><topic>Spinal Cord Compression - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HITCHON, P. W</creatorcontrib><creatorcontrib>MCKAY, T. C</creatorcontrib><creatorcontrib>WILKONSON, T. T</creatorcontrib><creatorcontrib>GIRTON, R. A. III</creatorcontrib><creatorcontrib>HANSEN, T</creatorcontrib><creatorcontrib>DYSTE, G. N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HITCHON, P. W</au><au>MCKAY, T. C</au><au>WILKONSON, T. T</au><au>GIRTON, R. A. III</au><au>HANSEN, T</au><au>DYSTE, G. N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylprednisolone in spinal cord compression</atitle><jtitle>Spine (Philadelphia, Pa. 1976)</jtitle><addtitle>Spine (Phila Pa 1976)</addtitle><date>1989</date><risdate>1989</risdate><volume>14</volume><issue>1</issue><spage>16</spage><epage>22</epage><pages>16-22</pages><issn>0362-2436</issn><eissn>1528-1159</eissn><coden>SPINDD</coden><abstract>In acute nonsurvival studies, eight anesthetized lambs were subjected to cord compression at T13 by means of an epidural balloon distended to a pressure of 200 mm Hg for 40 minutes. Subsequent to withdrawal of the balloon, each animal received 30 mg/kg of methylprednisolone succinate in an intravenous bolus followed by a continuous infusion of 10 mg/kg/hr for the duration of the experiment. Spinal cord blood flow (SCBF) and spinal evoked potential (SEP) determinations were obtained sequentially prior to, during, and at 1/2, 1 1/2, and 2 1/2 hours following compression. In spite of the absence of ischemia following compression, SEPs failed to recover. Methylprednisolone had no apparent effect on blood flow or on the recovery of SEPs when compared with results in ten control animals that received saline alone.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>2643834</pmid><doi>10.1097/00007632-198901000-00004</doi><tpages>7</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0362-2436
ispartof	Spine (Philadelphia, Pa. 1976), 1989, Vol.14 (1), p.16-22
issn	0362-2436 1528-1159
language	eng
recordid	cdi_proquest_miscellaneous_78828991
source	HEAL-Link subscriptions: Lippincott Williams & Wilkins
subjects	Animals Biological and medical sciences Evoked Potentials, Somatosensory - drug effects Female Male Medical sciences Methylprednisolone - analogs & derivatives Methylprednisolone Hemisuccinate - therapeutic use Nervous system involvement in other diseases. Miscellaneous Neurology Regional Blood Flow - drug effects Sheep Spinal Cord - blood supply Spinal Cord Compression - drug therapy Spinal Cord Compression - physiopathology
title	Methylprednisolone in spinal cord compression
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T00%3A57%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Methylprednisolone%20in%20spinal%20cord%20compression&rft.jtitle=Spine%20(Philadelphia,%20Pa.%201976)&rft.au=HITCHON,%20P.%20W&rft.date=1989&rft.volume=14&rft.issue=1&rft.spage=16&rft.epage=22&rft.pages=16-22&rft.issn=0362-2436&rft.eissn=1528-1159&rft.coden=SPINDD&rft_id=info:doi/10.1097/00007632-198901000-00004&rft_dat=%3Cproquest_cross%3E78828991%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c368t-3f1283dcb666b6e7ac767ffac8a91b794655eb042d864b64800649db31bbc4253%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=78828991&rft_id=info:pmid/2643834&rfr_iscdi=true