Dopamine D2 receptors quantified in vivo in human narcolepsy

Assays in brain tissues from humans suffering from narcolepsy, and from genetically narcoleptic dogs have suggested that dopamine function may be disturbed in this condition. We have used the specific D2 receptor ligand N-(3-[ 18F]fluoropropyl)-spiperone and positron tomography to study a group of 6...

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Bibliographic Details
Published in:Biological psychiatry (1969) 1997-02, Vol.41 (3), p.305-310
Main Authors: MacFarlane, J.G., List, S.J., Moldofsky, H., Firnau, Gunter, Chen, J.J., Szechtman, H., Garnett, S., Nahmias, Claude
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cerebrovascular Circulation
dopamine
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
human
Humans
Ligands
Male
Medical sciences
Narcolepsy
Narcolepsy - metabolism
Narcolepsy - physiopathology
Neostriatum - metabolism
Nervous system (semeiology, syndromes)
Neurology
positron emission tomography
Receptors, Dopamine D2 - metabolism
spiperone
Spiperone - analogs & derivatives
Tomography, Emission-Computed
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Summary:Assays in brain tissues from humans suffering from narcolepsy, and from genetically narcoleptic dogs have suggested that dopamine function may be disturbed in this condition. We have used the specific D2 receptor ligand N-(3-[ 18F]fluoropropyl)-spiperone and positron tomography to study a group of 6 well-characterized medication-free, HLA-DR2 DRW15 DW6-positive narcoleptic patients and a group of age- and sex-matched control individuals during life. We found no difference in striatal D2 receptor binding between these two groups. These results suggest that narcolepsy is not associated with alterations in D2 receptor density and affinity.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(96)00003-0