Protein-losing enteropathy in systemic lupus erythematosus: diagnosis and monitoring immunosuppressive therapy by alpha-1-antitrypsin clearance in stool

Enteric protein loss resulting in profound hypoalbuminemia and anasarca is an uncommon manifestation of systemic lupus erythematosus and only rarely is the initial presentation of disease. A few patients with SLE and protein-losing enteropathy in the absence of increased central venous pressure or i...

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Bibliographic Details
Published in:Digestive diseases and sciences 1989, Vol.34 (1), p.132-135
Main Authors: BENNER, K. G, MONTANARO, A
Format: Article
Language:English
Subjects:
Adult
alpha 1-Antitrypsin - analysis
Biological and medical sciences
Feces - analysis
Female
Humans
Immunosuppressive Agents - therapeutic use
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - drug therapy
Medical sciences
Protein-Losing Enteropathies - drug therapy
Protein-Losing Enteropathies - etiology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Enteric protein loss resulting in profound hypoalbuminemia and anasarca is an uncommon manifestation of systemic lupus erythematosus and only rarely is the initial presentation of disease. A few patients with SLE and protein-losing enteropathy in the absence of increased central venous pressure or intestinal lymphangiectasia have been reported. We describe the utility alpha-1-antitrypsin clearance in stool for diagnosing and monitoring enteric protein loss during successful immunosuppressive drug therapy in a patient who presented with massive enteric protein loss as the initial manifestation of systemic lupus erythematosus.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01536168