The human interleukin-1α gene is located on the long arm of chromosome 2 at band q13

• Published in: Blood 1989, Vol.73 (1), p.104-107
• Main Authors: LAFAGE, M, MAROC, N, DUBREUIL, P, DE WAAL MALEFIJT, R, PEBUSQUE, M.-J, CARCASSONNE, Y, MANNONI, P
• Format: Article
• Language: English
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Biological and medical sciences; Chromosome Banding; Chromosome Mapping; Chromosomes, Human, Pair 2; Deoxyribonucleases, Type III Site-Specific; DNA - isolation & purification; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genes; Humans; Immunobiology; Interleukin-1 - genetics; Lymphokines, interleukins ( function, expression); Male; Nucleic Acid Hybridization; Regulatory factors and their cellular receptors
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.v73.1.104.104

Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which was described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors. In this report we discuss our use of in situ hybridization on human prometaphase cells with a human IL-1 alpha cDNA probe to localize the human IL-1 alpha gene on the proximal part of the long arm of chromosome 2 at band q13, in the same chromosomal region as the IL-1 beta gene.