The human interleukin-1α gene is located on the long arm of chromosome 2 at band q13

Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. Recently, it has been shown that IL-1 alpha is identical to hematopoietin...

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Published in:Blood 1989, Vol.73 (1), p.104-107
Main Authors: LAFAGE, M, MAROC, N, DUBREUIL, P, DE WAAL MALEFIJT, R, PEBUSQUE, M.-J, CARCASSONNE, Y, MANNONI, P
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Biological and medical sciences
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 2
Deoxyribonucleases, Type III Site-Specific
DNA - isolation & purification
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Humans
Immunobiology
Interleukin-1 - genetics
Lymphokines, interleukins ( function, expression)
Male
Nucleic Acid Hybridization
Regulatory factors and their cellular receptors
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container_end_page 107
container_issue 1
container_start_page 104
container_title Blood
container_volume 73
creator LAFAGE, M
MAROC, N
DUBREUIL, P
DE WAAL MALEFIJT, R
PEBUSQUE, M.-J
CARCASSONNE, Y
MANNONI, P
description Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which was described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors. In this report we discuss our use of in situ hybridization on human prometaphase cells with a human IL-1 alpha cDNA probe to localize the human IL-1 alpha gene on the proximal part of the long arm of chromosome 2 at band q13, in the same chromosomal region as the IL-1 beta gene.
doi_str_mv 10.1182/blood.v73.1.104.104
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source ScienceDirect Journals
subjects Analysis of the immune response. Humoral and cellular immunity
Biological and medical sciences
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 2
Deoxyribonucleases, Type III Site-Specific
DNA - isolation & purification
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes
Humans
Immunobiology
Interleukin-1 - genetics
Lymphokines, interleukins ( function, expression)
Male
Nucleic Acid Hybridization
Regulatory factors and their cellular receptors
title The human interleukin-1α gene is located on the long arm of chromosome 2 at band q13
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