Crystalloid formation in gastrointestinal schwannoma

We found intracytoplasmic crystalloids in two of six cases (33.3%) of gastrointestinal (GI) schwannomas. The crystalloid inclusions were periodic acid-Schiff (PAS) positive with diastase-resistance and stained blue with Masson's trichrome. They were needleshaped and about 1 to 15 μm in length a...

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Bibliographic Details
Published in:Human pathology 1997-03, Vol.28 (3), p.304-308
Main Authors: Yagihashi, Norito, Kaimori, Mitsuomi, Katayama, Yosei, Yagihashi, Soroku
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
crystalloid
Cytoplasm - chemistry
Cytoplasm - ultrastructure
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Neoplasms - chemistry
Gastrointestinal Neoplasms - ultrastructure
gastrointestinal tract
Humans
Immunohistochemistry
Inclusion Bodies - ultrastructure
Male
Medical sciences
Microscopy, Electron
Middle Aged
Neurilemmoma - chemistry
Neurilemmoma - ultrastructure
S100 Proteins - analysis
schwannoma
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:We found intracytoplasmic crystalloids in two of six cases (33.3%) of gastrointestinal (GI) schwannomas. The crystalloid inclusions were periodic acid-Schiff (PAS) positive with diastase-resistance and stained blue with Masson's trichrome. They were needleshaped and about 1 to 15 μm in length at microscopic levels. They had varying electron density revealed by electron microscopy and some of them showed distinct lattice structure with periodicity of about 9 nm. Survey of soft tissue schwannomas ( n = 20) and S-100—negative GI stromal tumors ( n = 41) did not detect such crystalloids. Although the origin and differentiation of GI stromal tumors (GISTs) have been a source of controversy, these intracytoplasmic crystalloids may be a marker for Schwann cell differentiation in some GIST.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(97)90128-3