Respiratory Syncytial Virus Induces Selective Production of the Chemokine RANTES by Upper Airway Epithelial Cells

The presence of histamine and eosinophil cationic protein in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV)-induced bronchiolitis implies the activation of basophil and eosinophil leukocytes, but the specific mechanism of their recruitment has not been elucidated. Chemok...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-03, Vol.175 (3), p.497-504
Main Authors: Saito, Tadahito, Deskin, Ronald W., Casola, Antonella, Haeberle, Helene, Olszewska, Barbara, Ernst, Peter B., Alam, Rafeul, Ogra, Pearay L., Garofalo, Roberto
Format: Article
Language:English
Subjects:
Adenoids
Adenoids - cytology
Adenoids - metabolism
Adolescent
Adult
Biological and medical sciences
Cells, Cultured
Chemokine CCL5 - biosynthesis
Chemokines
Chemokines - biosynthesis
Cultured cells
Epithelial cells
Gene Expression
Human respiratory syncytial virus
Human viral diseases
Humans
Infections
Infectious diseases
Major Articles
Medical sciences
Middle Aged
Nasal Mucosa - immunology
Nasal Mucosa - microbiology
respiratory syncytial virus
Respiratory syncytial virus infections
Respiratory Syncytial Virus Infections - physiopathology
Respiratory syncytial viruses
RNA, Messenger - genetics
T lymphocytes
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viruses
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Summary:The presence of histamine and eosinophil cationic protein in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV)-induced bronchiolitis implies the activation of basophil and eosinophil leukocytes, but the specific mechanism of their recruitment has not been elucidated. Chemokines are potent and selective leukocyte chemotactic molecules that are also expressed by airway epithelial cells. Therefore, the pattern of chemokines produced in response to RSV infection was investigated in primary cultures of human nose- and adenoid-derived epithelial cells. Interleukin-8, growth-related peptide-α, and monocyte chemotactic protein-I were constitutively released by uninfected epithelial cells and were not further enhanced by infection with RSV. RANTES (regulated upon activation, normal T cell-expressed and -secreted), which was present in negligible concentrations in uninfected cultures, was strongly induced by RSV infection, in a dose- and timedependent manner. Through the release of RANTES, epithelial cells may control the selective concentration and activation of basophils and eosinophils in RSV-infected airway mucosa.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/175.3.497