The Influence of Age on the Prevalence of Hepatitis C Virus Subtypes 1a and 1b

The distribution of hepatitis C virus (HCV) genotypes was determined in isolates of 447chronically HCV-infected German patients by nucleotide sequencing. Of these, 206 (46.1%) were infected with the subtype la, 215 (48.1%) with subtype 1b, 2 (0.4%) with subtype 1c, 9 (2.0%) with subtype 3a, and 15 (...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-03, Vol.175 (3), p.685-688
Main Authors: Feucht, Heinz-Hubert, Schröter, Matthias, Zöllner, Bernhard, Polywka, Susanne, Nolte, Hartmut, Laufs, Rainer
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Base Sequence
Biological and medical sciences
Blood transfusion
Coinfection
Concise Communications
Female
Genotypes
Germany
Hepacivirus
Hepacivirus - genetics
Hepatitis C - drug therapy
Hepatitis C - microbiology
Hepatitis C virus
Human viral diseases
Humans
Infections
Infectious diseases
Interferon-alpha - therapeutic use
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Nucleotide sequences
Nucleotides
Polymerase chain reaction
Predisposing factors
Risk Factors
RNA, Viral - analysis
Sequencing
Time Factors
Viral diseases
Viral hepatitis
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Summary:The distribution of hepatitis C virus (HCV) genotypes was determined in isolates of 447chronically HCV-infected German patients by nucleotide sequencing. Of these, 206 (46.1%) were infected with the subtype la, 215 (48.1%) with subtype 1b, 2 (0.4%) with subtype 1c, 9 (2.0%) with subtype 3a, and 15 (3.4%) with subtype 4a. Subtype 1a was predominant in those 50 years old (84.7%; P < .001) and was associated with the risk factor of blood transfusions and with longer duration of disease. These data suggest that a shift from subtype 1b to subtype 1a occurred in the population studied. An increase in HCV infection with subtype 1a and a diminution of subtype 1b in the future can be expected.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/175.3.685