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The Influence of Age on the Prevalence of Hepatitis C Virus Subtypes 1a and 1b
The distribution of hepatitis C virus (HCV) genotypes was determined in isolates of 447chronically HCV-infected German patients by nucleotide sequencing. Of these, 206 (46.1%) were infected with the subtype la, 215 (48.1%) with subtype 1b, 2 (0.4%) with subtype 1c, 9 (2.0%) with subtype 3a, and 15 (...
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| Published in: | The Journal of infectious diseases 1997-03, Vol.175 (3), p.685-688 |
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| Main Authors: | , , , , , |
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| container_end_page | 688 |
| container_issue | 3 |
| container_start_page | 685 |
| container_title | The Journal of infectious diseases |
| container_volume | 175 |
| creator | Feucht, Heinz-Hubert Schröter, Matthias Zöllner, Bernhard Polywka, Susanne Nolte, Hartmut Laufs, Rainer |
| description | The distribution of hepatitis C virus (HCV) genotypes was determined in isolates of 447chronically HCV-infected German patients by nucleotide sequencing. Of these, 206 (46.1%) were infected with the subtype la, 215 (48.1%) with subtype 1b, 2 (0.4%) with subtype 1c, 9 (2.0%) with subtype 3a, and 15 (3.4%) with subtype 4a. Subtype 1a was predominant in those 50 years old (84.7%; P < .001) and was associated with the risk factor of blood transfusions and with longer duration of disease. These data suggest that a shift from subtype 1b to subtype 1a occurred in the population studied. An increase in HCV infection with subtype 1a and a diminution of subtype 1b in the future can be expected. |
| doi_str_mv | 10.1093/infdis/175.3.685 |
| format | article |
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Of these, 206 (46.1%) were infected with the subtype la, 215 (48.1%) with subtype 1b, 2 (0.4%) with subtype 1c, 9 (2.0%) with subtype 3a, and 15 (3.4%) with subtype 4a. Subtype 1a was predominant in those <40 years old (62.6%) and was associated with the risk factor of intravenous drug addiction and with shorter duration of disease. Conversely, subtype 1b was more frequent in patients >50 years old (84.7%; P < .001) and was associated with the risk factor of blood transfusions and with longer duration of disease. These data suggest that a shift from subtype 1b to subtype 1a occurred in the population studied. An increase in HCV infection with subtype 1a and a diminution of subtype 1b in the future can be expected.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/175.3.685</identifier><identifier>PMID: 9041344</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Age Factors ; Aged ; Base Sequence ; Biological and medical sciences ; Blood transfusion ; Coinfection ; Concise Communications ; Female ; Genotypes ; Germany ; Hepacivirus ; Hepacivirus - genetics ; Hepatitis C - drug therapy ; Hepatitis C - microbiology ; Hepatitis C virus ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Interferon-alpha - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Nucleotide sequences ; Nucleotides ; Polymerase chain reaction ; Predisposing factors ; Risk Factors ; RNA, Viral - analysis ; Sequencing ; Time Factors ; Viral diseases ; Viral hepatitis</subject><ispartof>The Journal of infectious diseases, 1997-03, Vol.175 (3), p.685-688</ispartof><rights>Copyright 1997 The University of Chicago</rights><rights>1997 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Mar 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-9884d711f9a33e8a1b0a88da6b863899228b860136eabe56bf7a1644f2ffade63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2612758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9041344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feucht, Heinz-Hubert</creatorcontrib><creatorcontrib>Schröter, Matthias</creatorcontrib><creatorcontrib>Zöllner, Bernhard</creatorcontrib><creatorcontrib>Polywka, Susanne</creatorcontrib><creatorcontrib>Nolte, Hartmut</creatorcontrib><creatorcontrib>Laufs, Rainer</creatorcontrib><title>The Influence of Age on the Prevalence of Hepatitis C Virus Subtypes 1a and 1b</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The distribution of hepatitis C virus (HCV) genotypes was determined in isolates of 447chronically HCV-infected German patients by nucleotide sequencing. Of these, 206 (46.1%) were infected with the subtype la, 215 (48.1%) with subtype 1b, 2 (0.4%) with subtype 1c, 9 (2.0%) with subtype 3a, and 15 (3.4%) with subtype 4a. Subtype 1a was predominant in those <40 years old (62.6%) and was associated with the risk factor of intravenous drug addiction and with shorter duration of disease. Conversely, subtype 1b was more frequent in patients >50 years old (84.7%; P < .001) and was associated with the risk factor of blood transfusions and with longer duration of disease. These data suggest that a shift from subtype 1b to subtype 1a occurred in the population studied. An increase in HCV infection with subtype 1a and a diminution of subtype 1b in the future can be expected.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blood transfusion</subject><subject>Coinfection</subject><subject>Concise Communications</subject><subject>Female</subject><subject>Genotypes</subject><subject>Germany</subject><subject>Hepacivirus</subject><subject>Hepacivirus - genetics</subject><subject>Hepatitis C - drug therapy</subject><subject>Hepatitis C - microbiology</subject><subject>Hepatitis C virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interferon-alpha - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Nucleotide sequences</subject><subject>Nucleotides</subject><subject>Polymerase chain reaction</subject><subject>Predisposing factors</subject><subject>Risk Factors</subject><subject>RNA, Viral - analysis</subject><subject>Sequencing</subject><subject>Time Factors</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkc1v1DAQxS1EVZbCnQuShRC3bG2P449jtQW2UtUCXRDiYk0SG7Jkk8VOEP3vcbXbrcSF01h-v3kz9iPkBWdzziyctn1o2nTKdTmHuTLlIzLjJehCKQ6PyYwxIQpurH1Cnqa0ZoxJUPqYHFsmOUg5I1erH55e9KGbfF97OgR69j2Xno75_kP0v7G7F5Z-i2M7toku6Jc2ToneTNV4u_WJcqTYN5RXz8hRwC755_t6Qj6_e7taLIvL6_cXi7PLopYGxsIaIxvNebAI4A3yiqExDarKKMjrCmHyiXFQHitfqipo5ErKIELAxis4IW92vts4_Jp8Gt2mTbXvOuz9MCWnjQGrBPwX5KXNU0Bn8NU_4HqYYp8f4YQAy6UWLENsB9VxSCn64Lax3WC8dZy5u0DcLhCXA3HgciC55eXed6o2vjk07BPI-uu9jqnGLkTs62xwjwnFhS7Ng806jUM8yJD_iLHybkyx09s0-j8HHeNPpzTkbZZfv7mbTx_ZeblauBX8BS-Aqls</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Feucht, Heinz-Hubert</creator><creator>Schröter, Matthias</creator><creator>Zöllner, Bernhard</creator><creator>Polywka, Susanne</creator><creator>Nolte, Hartmut</creator><creator>Laufs, Rainer</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970301</creationdate><title>The Influence of Age on the Prevalence of Hepatitis C Virus Subtypes 1a and 1b</title><author>Feucht, Heinz-Hubert ; 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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1997-03, Vol.175 (3), p.685-688 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Adult Age Factors Aged Base Sequence Biological and medical sciences Blood transfusion Coinfection Concise Communications Female Genotypes Germany Hepacivirus Hepacivirus - genetics Hepatitis C - drug therapy Hepatitis C - microbiology Hepatitis C virus Human viral diseases Humans Infections Infectious diseases Interferon-alpha - therapeutic use Male Medical sciences Middle Aged Molecular Sequence Data Nucleotide sequences Nucleotides Polymerase chain reaction Predisposing factors Risk Factors RNA, Viral - analysis Sequencing Time Factors Viral diseases Viral hepatitis |
| title | The Influence of Age on the Prevalence of Hepatitis C Virus Subtypes 1a and 1b |
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