Borrelia burgdorferi—associated primary cutaneous B cell lymphoma: complete clearing of skin lesions after antibiotic pulse therapy or intralesional injection of interferon alfa-2a

We report two patients with low-grade malignant primary cutaneous B cell lymphoma in association with Borrelia burgdorferi infection. Extracutaneous manifestations were ruled out by standard staging procedures. Infection with Borrelia burgdorferi was confirmed by cultivation from lesional skin in bo...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1997-02, Vol.36 (2), p.311-314
Main Authors: Kütting, Birgitta, Bonsmann, Gisela, Metze, Dieter, Luger, Thomas A., Cerroni, Lorenzo
Format: Article
Language:English
Subjects:
Adult
Bacterial diseases
Biological and medical sciences
Borrelia burgdorferi Group - isolation & purification
Borrelia infections
Cefotaxime - administration & dosage
Ceftriaxone - administration & dosage
Doxycycline - administration & dosage
Drug Administration Schedule
Drug Therapy, Combination - administration & dosage
Human bacterial diseases
Humans
Infectious diseases
Injections, Intralesional
Interferon alpha-2
Interferon-alpha - administration & dosage
Lyme Disease - complications
Lymphoma, B-Cell - etiology
Male
Medical sciences
Recombinant Proteins
Recurrence
Tropical bacterial diseases
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Summary:We report two patients with low-grade malignant primary cutaneous B cell lymphoma in association with Borrelia burgdorferi infection. Extracutaneous manifestations were ruled out by standard staging procedures. Infection with Borrelia burgdorferi was confirmed by cultivation from lesional skin in both patients. In the first patient skin lesions cleared completely after pulse therapy with cefotaxime, whereas in the second patient antibiotic treatment failed. In this patient, however, skin lesions completely cleared after intralesional injection of interferon alfa-2a. Antibiotic treatment or intralesional injection of interferon alfa-2a should be considered as a first-line treatment of Borrelia burgdorferi—associated primary cutaneous B cell lymphoma before more aggressive conventional therapeutic modalities (e.g., radiation therapy) are applied.
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(97)80405-7