Progressive multifocal leukoencephalopathy in an HIV-infected child

A child with perinatally acquired HIV infection presented with acute neurologic deterioration. A cerebellar white matter lesion seen on CT and MRI later proved to be progressive multifocal leukoencephalopathy (PML) by histology. Although a recognized disease of HIV-infected adults, PML is certain to...

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Bibliographic Details
Published in:Neuroradiology 1997-02, Vol.39 (2), p.142-144
Main Authors: MORRISS, M. C, RUTSTEIN, R. M, RUDY, B, DESROCHERS, C, HUNTER, J. V, ZIMMERMAN, R. A
Format: Article
Language:English
Subjects:
AIDS Dementia Complex - diagnosis
AIDS Dementia Complex - pathology
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - pathology
AIDS/HIV
Biological and medical sciences
Biopsy
Brain - pathology
Child
Diagnosis, Differential
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Leukoencephalopathy, Progressive Multifocal - diagnosis
Leukoencephalopathy, Progressive Multifocal - pathology
Magnetic Resonance Imaging
Male
Medical sciences
Neurologic Examination
Tomography, X-Ray Computed
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Summary:A child with perinatally acquired HIV infection presented with acute neurologic deterioration. A cerebellar white matter lesion seen on CT and MRI later proved to be progressive multifocal leukoencephalopathy (PML) by histology. Although a recognized disease of HIV-infected adults, PML is certain to be seen with more frequency in HIV-infected children who are surviving longer as a result of improved medical care. Recognition of the clinical and radiographic manifestations is important because of the dismal prognosis.
ISSN:0028-3940
1432-1920
DOI:10.1007/s002340050383