A Genetic Polymorphism in the Renin Gene of Dahl Rats Cosegregates with Blood Pressure

Blood pressure is influenced by multiple genetic loci whose identities are largely unknown. A restriction fragment length polymorphism (RFLP) in the renin gene was found between Dahl salt-hypertension--sensitive (S) and Dahl salt-hypertension--resistant (R) rats. In an F$_{2}$ population derived fro...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1989-01, Vol.243 (4890), p.542-544
Main Authors: Rapp, John P., Wang, Sue-May, Dene, Howard
Format: Article
Language:English
Subjects:
Alleles
Animals
Blood plasma
Blood pressure
Blood Pressure - drug effects
Blotting, Southern
DNA Probes
Female
Genetic aspects
Genetic loci
Genetics
Genotype
Genotypes
Hypertension
Hypertension - genetics
Inbred strains
Inbreeding
Laboratory rats
Linkage (Genetics)
Male
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Population growth
Rats
Rats as laboratory animals
Rats, Inbred Strains
Renin
Renin - genetics
Sodium Chloride - pharmacology
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Summary:Blood pressure is influenced by multiple genetic loci whose identities are largely unknown. A restriction fragment length polymorphism (RFLP) in the renin gene was found between Dahl salt-hypertension--sensitive (S) and Dahl salt-hypertension--resistant (R) rats. In an F$_{2}$ population derived from crossing S and R rats, the renin RFLP cosegregated with blood pressure. One dose of the S-rat renin allele was associated with an increment in blood pressure of approximately 10 mmHg, and two doses of this allele increased blood pressure approximately 20 mmHg. From this it can be definitively concluded that in the rat the renin gene is, or is closely linked to, one of the genes regulating blood pressure.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2563177