Human NK cells: their ligands, receptors and functions

The expression, or lack thereof, of class I MHC glycoproteins has a marked influence on natural killer cell function. Cells which do not express class I MHC molecules are susceptible to lysis by NK cells, and transfection of these targets with class I MHC genes can render these cells resistant to NK...

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Bibliographic Details
Published in:Immunological reviews 1997-02, Vol.155 (1), p.119-125
Main Authors: Reyburn, Hugh, Mandelboim, Ofer, Valés-Goméz, Mar, Sheu, Eric G., Pazmany, Laszio, Davis, Daniel M., Strominger, Jack L.
Format: Article
Language:English
Subjects:
Humans
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Ligands
Receptors, Immunologic - physiology
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Summary:The expression, or lack thereof, of class I MHC glycoproteins has a marked influence on natural killer cell function. Cells which do not express class I MHC molecules are susceptible to lysis by NK cells, and transfection of these targets with class I MHC genes can render these cells resistant to NK attack. This inhibition of NK‐killing is mediated by a novel family of receptors expressed mainly on NK cells, but also found on some T‐cells. The function of these class I MHC binding receptors when expressed on T‐cells is discussed also and a novel co‐stimulatory activity of NKAR described. Lastly, a novel mechanism by which human cytomegalovirus evades immune surveillance by NK cells is documented.
ISSN:0105-2896
1600-065X
DOI:10.1111/j.1600-065X.1997.tb00944.x