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Effects of long-term training on the progression of chronic renal failure in rats
To evaluate the effects of long-term exercise on the progression of chronic renal failure (CRF), adult Munich-Wistar rats with 5/6 renal mass ablation were submitted to treadmill exercise for 30 min 5 times/wk for 60 d. Whole kidney function and glomerular hemodynamics, proteinuria, and glomerular s...
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Published in: | Medicine and science in sports and exercise 1997-02, Vol.29 (2), p.169-174 |
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description | To evaluate the effects of long-term exercise on the progression of chronic renal failure (CRF), adult Munich-Wistar rats with 5/6 renal mass ablation were submitted to treadmill exercise for 30 min 5 times/wk for 60 d. Whole kidney function and glomerular hemodynamics, proteinuria, and glomerular sclerosis were evaluated in 4 groups: Control, Sham trained (Sham + Ex), rats submitted to 5/6 nephrectomy (CRF) and maintained sedentary, and rats with 5/6 nephrectomy and trained (CRF + Ex). The groups with chronic renal failure (sedentary and trained) presented a reduction in total glomerular filtration rate (GFR) and in renal plasma flow (RPF), accompanied by an increase in single nephron GFR (SNGFR) and glomerular plasma flow (QA). However, the CRF + EX group did not show the glomerular hypertension observed in the CRF group. Despite the normalization of glomerular hypertension, proteinuria and sclerosis index were not different from the CRF sedentary group. Physical training provoked a vasodilatation of efferent arterioles, which induced the normalization of glomerular hypertension. These results suggest that the reduction alone of glomerular hypertension induced by exercise does not prevent the progression of renal disease, indicating the participation of other associated factors in this experimental model. |
doi_str_mv | 10.1097/00005768-199702000-00001 |
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However, the CRF + EX group did not show the glomerular hypertension observed in the CRF group. Despite the normalization of glomerular hypertension, proteinuria and sclerosis index were not different from the CRF sedentary group. Physical training provoked a vasodilatation of efferent arterioles, which induced the normalization of glomerular hypertension. 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Renal failure ; Oxygen Consumption ; Physical Conditioning, Animal - physiology ; Proteinuria ; Rats ; Renal failure ; Sclerosis ; Space life sciences</subject><ispartof>Medicine and science in sports and exercise, 1997-02, Vol.29 (2), p.169-174</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-f820b278a19bda5cd15f5a084dbc8c3f15a36b2e98814d83716f7a249c8ec2043</citedby><cites>FETCH-LOGICAL-c455t-f820b278a19bda5cd15f5a084dbc8c3f15a36b2e98814d83716f7a249c8ec2043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2603122$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9044218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERGAMASCHI, C. T</creatorcontrib><creatorcontrib>BOIM, M. A</creatorcontrib><creatorcontrib>MOURA, L. A</creatorcontrib><creatorcontrib>PICARRO, I. C</creatorcontrib><creatorcontrib>SCHOR, N</creatorcontrib><title>Effects of long-term training on the progression of chronic renal failure in rats</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>To evaluate the effects of long-term exercise on the progression of chronic renal failure (CRF), adult Munich-Wistar rats with 5/6 renal mass ablation were submitted to treadmill exercise for 30 min 5 times/wk for 60 d. Whole kidney function and glomerular hemodynamics, proteinuria, and glomerular sclerosis were evaluated in 4 groups: Control, Sham trained (Sham + Ex), rats submitted to 5/6 nephrectomy (CRF) and maintained sedentary, and rats with 5/6 nephrectomy and trained (CRF + Ex). The groups with chronic renal failure (sedentary and trained) presented a reduction in total glomerular filtration rate (GFR) and in renal plasma flow (RPF), accompanied by an increase in single nephron GFR (SNGFR) and glomerular plasma flow (QA). However, the CRF + EX group did not show the glomerular hypertension observed in the CRF group. Despite the normalization of glomerular hypertension, proteinuria and sclerosis index were not different from the CRF sedentary group. Physical training provoked a vasodilatation of efferent arterioles, which induced the normalization of glomerular hypertension. These results suggest that the reduction alone of glomerular hypertension induced by exercise does not prevent the progression of renal disease, indicating the participation of other associated factors in this experimental model.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Glomerular Filtration Rate</subject><subject>Hemodynamics</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Glomerulus - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Oxygen Consumption</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Proteinuria</subject><subject>Rats</subject><subject>Renal failure</subject><subject>Sclerosis</subject><subject>Space life sciences</subject><issn>0195-9131</issn><issn>1530-0315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNo9kU9PAyEQxYnR1Fr9CCYcjLdVBpYFjqbxX9LEmOh5w7LQYrZshd2D315q13Ih781vZsgDIQzkDogS9yQfLipZgFKC0KyKvQUnaA6cZcGAn6I5AcULBQzO0UVKX5kQjMEMzRQpSwpyjt4fnbNmSLh3uOvDuhhs3OIhah98WOM-4GFj8S7262hT8lln0GxiH7zB0QbdYad9N0aLfcBRD-kSnTndJXs13Qv0-fT4sXwpVm_Pr8uHVWFKzofCSUoaKqQG1bSamxa445rIsm2MNMwB16xqqFVSQtlKJqByQtNSGWkNJSVboNvD3Py479Gmod76ZGzX6WD7MdVCylJQgAzKA2hin1K0rt5Fv9XxpwZS79Os_9Osj2n-WfvW62nH2Gxte2yc4sv1m6muk9GdizoYn44YrfI_UMp-AYLnfBE</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>BERGAMASCHI, C. T</creator><creator>BOIM, M. 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Renal failure</topic><topic>Oxygen Consumption</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Proteinuria</topic><topic>Rats</topic><topic>Renal failure</topic><topic>Sclerosis</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERGAMASCHI, C. T</creatorcontrib><creatorcontrib>BOIM, M. A</creatorcontrib><creatorcontrib>MOURA, L. A</creatorcontrib><creatorcontrib>PICARRO, I. 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C</au><au>SCHOR, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of long-term training on the progression of chronic renal failure in rats</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>29</volume><issue>2</issue><spage>169</spage><epage>174</epage><pages>169-174</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><coden>MSPEDA</coden><abstract>To evaluate the effects of long-term exercise on the progression of chronic renal failure (CRF), adult Munich-Wistar rats with 5/6 renal mass ablation were submitted to treadmill exercise for 30 min 5 times/wk for 60 d. Whole kidney function and glomerular hemodynamics, proteinuria, and glomerular sclerosis were evaluated in 4 groups: Control, Sham trained (Sham + Ex), rats submitted to 5/6 nephrectomy (CRF) and maintained sedentary, and rats with 5/6 nephrectomy and trained (CRF + Ex). The groups with chronic renal failure (sedentary and trained) presented a reduction in total glomerular filtration rate (GFR) and in renal plasma flow (RPF), accompanied by an increase in single nephron GFR (SNGFR) and glomerular plasma flow (QA). However, the CRF + EX group did not show the glomerular hypertension observed in the CRF group. Despite the normalization of glomerular hypertension, proteinuria and sclerosis index were not different from the CRF sedentary group. Physical training provoked a vasodilatation of efferent arterioles, which induced the normalization of glomerular hypertension. 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subjects | Animals Biological and medical sciences Disease Models, Animal Disease Progression Glomerular Filtration Rate Hemodynamics Kidney Failure, Chronic - physiopathology Kidney Glomerulus - physiopathology Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Oxygen Consumption Physical Conditioning, Animal - physiology Proteinuria Rats Renal failure Sclerosis Space life sciences |
title | Effects of long-term training on the progression of chronic renal failure in rats |
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