Sperm quality in Hodgkin's disease versus non-Hodgkin's lymphoma

The study was conducted to determine the deleterious effect of lymphoma disease on spermatogenesis and to evaluate the possibility that the disease is mediated primarily by inherent mechanisms in Hodgkin's disease and non-Hodgkin's lymphoma patients. A total of 89 patients with lymphoma di...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1997-01, Vol.12 (1), p.73-76
Main Authors: Botchan, A, Hauser, R, Gamzu, R, Yogev, L, Lessing, J B, Paz, G, Yavetz, H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cryopreservation
Fertilization in Vitro
Follicle Stimulating Hormone - blood
Hematologic and hematopoietic diseases
Hodgkin Disease - pathology
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Non-Hodgkin - pathology
Male
Medical sciences
Middle Aged
Semen Preservation
Sperm Count
Sperm Motility
Spermatogenesis
Spermatozoa - physiology
Testis - pathology
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Summary:The study was conducted to determine the deleterious effect of lymphoma disease on spermatogenesis and to evaluate the possibility that the disease is mediated primarily by inherent mechanisms in Hodgkin's disease and non-Hodgkin's lymphoma patients. A total of 89 patients with lymphoma disease (Hodgkin's and non-Hodgkin's) were referred for sperm preservation prior to adjuvant treatments. A comparison was made of pre- and post-thaw sperm quality between lymphoma patients and healthy volunteers who applied for sperm donation. This was followed by further assessment of the differences between patients with Hodgkin's disease and non-Hodgkin's lymphoma in terms of sperm variables, clinical parameters and blood hormone concentrations. It was found that patients with lymphoma disease had significantly impaired pre-freeze and post-thaw sperm quality compared with that of healthy volunteers. Patients with non-Hodgkin's lymphoma had spermatozoa of higher quality than patients with Hodgkin's disease. No differences were found in the clinical or hormonal parameters between these two groups. As expected, reduced testicular size and abnormal testicular consistency were correlated with decreased sperm quality. The mere presence of cancer disease has a direct negative effect on spermatogenesis, which is probably not related to incidental side-effects. A variable degree of impairment should be expected with different categories of cancer.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/12.1.73