Vitamin D Metabolite-Mediated Hypercalcemia and Hypercalciuria Patients With AIDS- and Non-AIDS-Associated Lymphoma

Fifteen patients with lymphoma and hypercalcemia (≥ 11.0 mg/dL) were identified by screening the serum chemistry profile obtained from patients upon admission to the Los Angeles County/USC Medical Center. Seven of the 15 (47%) possessed a frankly elevated serum concentration of 1,25-dihydroxyvitamin...

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Bibliographic Details
Published in:Blood 1989-01, Vol.73 (1), p.235-239
Main Authors: Adams, John S., Fernandez, Manuel, Gacad, Mercedes A., Gill, Parkash S., Endres, David B., Rasheed, Suraiya, Singer, Frederick R.
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS/HIV
Calcitriol - blood
Calcitriol - physiology
Calcium - blood
Calcium - urine
Female
Humans
Hypercalcemia - blood
Hypercalcemia - etiology
Hypercalcemia - urine
Leukemia-Lymphoma, Adult T-Cell - blood
Leukemia-Lymphoma, Adult T-Cell - complications
Leukemia-Lymphoma, Adult T-Cell - urine
Lymphoma - blood
Lymphoma - complications
Lymphoma - urine
Male
Middle Aged
Prospective Studies
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Summary:Fifteen patients with lymphoma and hypercalcemia (≥ 11.0 mg/dL) were identified by screening the serum chemistry profile obtained from patients upon admission to the Los Angeles County/USC Medical Center. Seven of the 15 (47%) possessed a frankly elevated serum concentration of 1,25-dihydroxyvitamin D [1,25-(OH)2-D]. An additional patient with severe hypercalcemia (16.2 mg/dL) had a serum 1,25-(OH)2-D concentration in the midnormal range, not a suppressed value. To examine the potential existence of hypercalciuria in absence of overt hypercalcemia, prospective screening of 23 normocalcemic patients with lymphoma was undertaken. Four of the 23 patients (17%) had increased fractional urinary calcium excretion rates (0.35 ± 0.3 mg calcium/100 mL glomerular filtrate [GF], mean ± SE; normal,
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V73.1.235.235