THE RELATIONSHIP BETWEEN SECOND-TRIMESTER AMNIOTIC FLUID INSULIN AND GLUCOSE LEVELS AND SUBSEQUENT GESTATIONAL DIABETES

• Published in: Prenatal diagnosis 1997-02, Vol.17 (2), p.149-154
• Main Authors: STAR, JAMI, CANICK, JACOB A., PALOMAKI, GLENN E., SALLER, DEVEREUX N., SUNG, C. JAMES, TUMBER, MAREA B., COUSTAN, DONALD R.
• Format: Article
• Language: English
• Subjects: Adult; Amniocentesis; Amniotic Fluid - chemistry; amniotic fluid glucose; amniotic fluid insulin; Biological and medical sciences; Diabetes, Gestational - diagnosis; Diabetes, Gestational - metabolism; Female; gestational diabetes; Glucose - analysis; Gynecology. Andrology. Obstetrics; Humans; Insulin - analysis; Management. Prenatal diagnosis; Maternal Age; Medical sciences; Pregnancy; Pregnancy Trimester, Second; Pregnancy, High-Risk; Pregnancy. Fetus. Placenta
• ISSN: 0197-3851; 1097-0223
• DOI: 10.1002/(SICI)1097-0223(199702)17:2<149::AID-PD48>3.0.CO;2-S

Associations between elevated amniotic fluid glucose and insulin levels in the second trimester and the subsequent development of gestational diabetes have been reported. We conducted a case–control study to determine which analyte best predicts future maternal glucose intolerance. Thirty‐nine women diagnosed with gestational diabetes (criteria of Carpenter and Coustan, Am. J. Obstet. Gynecol., 144,768, 1982) who had undergone genetic amniocentesis for advanced maternal age were matched with euglycaemic controls. Glucose and insulin concentrations were determined by analysis of stored amniotic fluid samples. No significant difference was detected between cases and controls for amniotic fluid glucose concentrations. Amniotic fluid insulin concentrations were significantly higher in cases (mean rank 4·44, P