Elimination of blood-derived macrophages inhibits the release of interleukin-1 and the entry of leukocytes into the cerebrospinal fluid in experimental pneumococcal meningitis

Parameters of inflammation during pneumococcal meningitis were determined in rabbits after monocyte elimination by dichloromethylene diphosphonate (Cl 2MDP)-containing mannosylated liposomes in comparison with untreated controls. Monocyte depletion reduced the migration of white blood cells into the...

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Bibliographic Details
Published in:Journal of neuroimmunology 1997-03, Vol.73 (1), p.77-80
Main Authors: Zysk, Gregor, Brück, Wolfgang, Huitinga, Ingeborg, Fischer, Falko R, Flachsbarth, Franziska, van Rooijen, Nico, Nau, Roland
Format: Article
Language:English
Subjects:
Animals
Blood Cells - drug effects
Blood Cells - physiology
Body Temperature
Cell Movement
Cerebrospinal Fluid - cytology
Clodronic Acid - pharmacology
Dichloromethylene diphosphonate
Interleukin-1 - metabolism
Interleukin-1 β
Leukocytes - physiology
Liposomes
Macrophages
Macrophages - drug effects
Macrophages - physiology
Meningitis
Meningitis, Pneumococcal - cerebrospinal fluid
Meningitis, Pneumococcal - pathology
Rabbits
Streptococcus pneumoniae
Time Factors
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Summary:Parameters of inflammation during pneumococcal meningitis were determined in rabbits after monocyte elimination by dichloromethylene diphosphonate (Cl 2MDP)-containing mannosylated liposomes in comparison with untreated controls. Monocyte depletion reduced the migration of white blood cells into the cerebrospinal fluid (CSF) (medians: 42 versus 2146/mm 3 at 18 h, 323 versus 7413/mm 3 at 24 h p.i., p
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(96)00173-7