Antiperoxidative Activity of Neolignans from Magnolia obovata

Honokiol and magnolol, neolignans in Magnolia obovata, have been evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)‐ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)‐ADP/NADH were inhibited by these compounds. These neolignans protected mitochondrial respirat...

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Published in:Journal of pharmacy and pharmacology 1997-02, Vol.49 (2), p.209-212
Main Authors: HARAGUCHI, HIROYUKI, ISHIKAWA, HARUMI, SHIRATAKI, NORITOSHI, FUKUDA, AYUMI
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Biological and medical sciences
Biphenyl Compounds - pharmacology
Drugs, Chinese Herbal - pharmacology
Erythrocytes - drug effects
General pharmacology
Hemolysis - drug effects
Lignans - pharmacology
Lipid Peroxidation
Male
Medical sciences
Microsomes, Liver - drug effects
Microsomes, Liver - metabolism
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rats
Rats, Wistar
Trees
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Summary:Honokiol and magnolol, neolignans in Magnolia obovata, have been evaluated as antioxidants. Microsomal lipid peroxidation induced by Fe(III)‐ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)‐ADP/NADH were inhibited by these compounds. These neolignans protected mitochondrial respiratory chain enzyme activity against NADPH‐induced peroxidative stress and protected red cells against oxidative haemolysis. The anti‐oxidative activity of honokiol was more potent than that of magnolol. Neolignans in M. obovata were shown to be effective in protecting biological systems and functions against oxidative stress.
ISSN:0022-3573
2042-7158
DOI:10.1111/j.2042-7158.1997.tb06781.x