Antineoplastic Agents. 362. Isolation and X-ray Crystal Structure of Dibromophakellstatin from the Indian Ocean Sponge Phakellia mauritiana

Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized....

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1997-02, Vol.60 (2), p.180-183
Main Authors: Pettit, George R, McNulty, James, Herald, Delbert L, Doubek, Dennis L, Chapuis, Jean-Charles, Schmidt, Jean M, Tackett, Larry P, Boyd, Michael R
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
Animals
ANTINEOPLASTIC AGENTS
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
BIOASSAYS
Biological and medical sciences
CELL CULTURE
CELL LINES
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
CHEMISTRY
CHIMIE
COMPOSE HETEROCYCLIQUE
COMPOSE ORGANOAZOTE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
COMPUESTO ORGANICO DEL NITROGENO
COMPUESTOS HETEROCICLICOS
Crystallography, X-Ray
CULTIVO DE CELULAS
CULTURE DE CELLULE
CYTOTOXIC COMPOUNDS
DEBROMOHYMENIALOSINE
DEOXYRIBONUCLEOSIDE
DEOXYRIBONUCLEOSIDES
DEOXYURIDINE
DESOXIRIBONUCLEOSIDOS
DIBROMOPHAKELLIN
DOSAGE BIOLOGIQUE
Drug Screening Assays, Antitumor
ENSAYO BIOLOGICO
ESPECTROMETRIA
ESTRUCTURA QUIMICA
General pharmacology
HETEROCYCLIC COMPOUNDS
HUMAN TUMOR CELL LINES
Humans
Imidazoles - chemistry
Imidazoles - isolation & purification
Imidazoles - pharmacology
INDIAN OCEAN
Marine
Medical sciences
MEDICAMENT CYTOSTATIQUE
Molecular Structure
OCEAN INDIEN
OCEANO INDICO
ORGANIC NITROGEN COMPOUNDS
PARAZOA
Phakellia mauritiana
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera
Porifera - chemistry
QUIMICA
SEYCHELLES
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
STEREOCHEMISTRY
STRUCTURE CHIMIQUE
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
THYMIDINE
THYMINE
TIMIDINA
TIMINA
TOXIC SUBSTANCES
Tumor Cells, Cultured
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Summary:Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thymine.
ISSN:0163-3864
1520-6025
DOI:10.1021/np9606106