GLYCOPYRRONIUM REQUIREMENTS FOR ANTAGONISM OF THE MUSCARINIC SIDE EFFECTS OF EDROPHONIUM

We have compared, in 60 adult patients, the cardiovascular effects of glycopyrronium 5 µg kg−1 and 10 µg kg−1 given either simultaneously or 1 min before edrophonium 1 µg kg−1. Significant differences between the four groups were detected (P < 0.001). Both groups receiving 10 µg kg−1 showed incre...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1989-01, Vol.62 (1), p.77-81
Main Authors: DODD, P., DAY, S.J., GOLDHILL, D.R., MACLEOD, D.M., WITHINGTON, P.S., YATE, P.M.
Format: Article
Language:English
Subjects:
Adult
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Edrophonium - administration & dosage
Edrophonium - antagonists & inhibitors
Female
Glycopyrrolate - administration & dosage
Glycopyrrolate - pharmacology
Heart Rate - drug effects
Humans
Male
Medical sciences
Neuropharmacology
Oropharynx - drug effects
Pharmacology. Drug treatments
Pyrrolidines - administration & dosage
Time Factors
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Summary:We have compared, in 60 adult patients, the cardiovascular effects of glycopyrronium 5 µg kg−1 and 10 µg kg−1 given either simultaneously or 1 min before edrophonium 1 µg kg−1. Significant differences between the four groups were detected (P < 0.001). Both groups receiving 10 µg kg−1 showed increases in heart rate of up to 30 beat min-1 (95% confidence limits 28–32 beat min-1). Use of glycopyrronium 5 µg kg−1 provided greater cardiovascular stability and, given 1 min before the edrophonium, was sufficient to minimize early, edrophonium-induced bradycardias. This low dose of glycoprronium provided good control of oropharyngeal secretions.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/62.1.77