Free radical scavenging activities of mushroom polysaccharide extracts

The superoxide and hydroxyl radical scavenging activities of eight mushroom antitumor polysaccharide extracts were investigated using phenazin methosulphate-NADH-nitroblue tetrazolium system and ascorbic acid-Cu 2+-cytochrome C system respectively. The results showed that six of eight mushroom polys...

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Bibliographic Details
Published in:Life sciences (1973) 1997, Vol.60 (10), p.763-771
Main Authors: Liu, F., Ooi, V.E.C., Chang, S.T.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Basidiomycota - chemistry
free radical
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
Fungal Proteins - analysis
Hydroxyl Radical - metabolism
Lentinan - chemistry
Lentinan - pharmacology
Lipid Peroxidation - drug effects
Malondialdehyde - metabolism
malondialdehyde dismutase
mushroom
oxidative stress
polysaccharide
Polysaccharides - chemistry
Polysaccharides - pharmacology
Proteoglycans - chemistry
Proteoglycans - pharmacology
Superoxides - metabolism
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Summary:The superoxide and hydroxyl radical scavenging activities of eight mushroom antitumor polysaccharide extracts were investigated using phenazin methosulphate-NADH-nitroblue tetrazolium system and ascorbic acid-Cu 2+-cytochrome C system respectively. The results showed that six of eight mushroom polysaccharide extracts had superoxide and hydroxyl radical scavenging activities. The protein content of the polysaccharide extracts appeared to contribute a direct effect on free radical scavenging activity. However, none of the mushroom polysaccharide extracts had antioxidative activity as measured by detecting malondialdehyde (MDA) contents of liver microsomes.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(97)00004-0