Electrostimulation‐induced fast‐to‐slow transitions of myosin light and heavy chains in rabbit fast‐twitch muscle at the mRNA level

Chronic low‐frequency stimulation of rabbit fast‐twitch muscle induces progressive increases in slow myosin light chain mRNAs followed by an increase in the slow myosin heavy chain HCI mRNA. Therefore, the effects of chronic stimulation are more pronounced in rabbit than in rat fast‐twitch muscle. T...

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Bibliographic Details
Published in:FEBS letters 1989-01, Vol.243 (2), p.123-126
Main Authors: Kirschbaum, Bernhard J., Heilig, Annegard, Härtner, Karl-Thomas, Pette, Dirk
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell physiology
Chronic electrostimulation
Effects of physical and chemical agents
Electric Stimulation
Endonucleases
Fast-twitch muscle
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
mRNA
Muscle Contraction
Muscles - metabolism
Muscles - physiology
Myosin heavy chain isoform
Myosin light chain isoform
Myosins - genetics
Myosins - metabolism
Protein Biosynthesis
Rabbits
Restriction Mapping
RNA, Messenger - metabolism
Single-Strand Specific DNA and RNA Endonucleases
Time Factors
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Summary:Chronic low‐frequency stimulation of rabbit fast‐twitch muscle induces progressive increases in slow myosin light chain mRNAs followed by an increase in the slow myosin heavy chain HCI mRNA. Therefore, the effects of chronic stimulation are more pronounced in rabbit than in rat fast‐twitch muscle. The latter responds mainly with a rearrangement of its fast isomyosin pattern.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(89)80112-7