Oxyphil and squamous variants of medullary thyroid carcinoma

Two unusual morphologic variants of medullary thyroid carcinoma not previously described are reported. The first tumor was composed predominantly of large eosinophilic cells indistinguishable at the light microscopic level from Hürthle cells. Focal areas of conventional medullary carcinoma were also...

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Bibliographic Details
Published in:Cancer 1989-03, Vol.63 (6), p.1183-1188
Main Authors: Dominguez‐Malagon, Hugo, Delgado‐Chavez, Ricardo, Torres‐Najera, Manuel, Gould, Edwin, Albores‐Saavedra, Jorge
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Calcitonin - analysis
Carcinoembryonic Antigen - analysis
Carcinoma - pathology
Carcinoma - secondary
Carcinoma, Squamous Cell - pathology
Chromogranins - analysis
Cytoplasmic Granules - ultrastructure
Endocrinopathies
Female
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Malignant tumors
Medical sciences
Mitochondria - ultrastructure
Phosphopyruvate Hydratase - analysis
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
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Summary:Two unusual morphologic variants of medullary thyroid carcinoma not previously described are reported. The first tumor was composed predominantly of large eosinophilic cells indistinguishable at the light microscopic level from Hürthle cells. Focal areas of conventional medullary carcinoma were also present. Electron microscopic study showed mitochondrion‐rich cells containing round neurosecretory granules. Immunoreactive calcitonin and carcinoembryonic antigen (CEA) were demonstrated within most tumor cells. The second tumor had areas of typical medullary carcinoma but exhibited extensive squamous differentiation. The tumor was positive for CEA, neuron‐specific enolase, and chromogranin but negative for calcitonin. Oxyphil and squamous cells must be added to the long list of cell types that have been described in medullary thyroid carcinoma.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19890315)63:6<1183::AID-CNCR2820630624>3.0.CO;2-3