Inhibition of Metastases of a Human Melanoma Xenograft by Monoclonal Antibody to the GD2/GD3 Gangliosides

A human melanoma variant cell line was obtained from a lung metastasis that arose spontaneously after we inoculated melanoma cells sc into a nude mouse. In this model, IGG2a monoclonal antibody (MAb) ME 36.1 defining the GD2/GD3 gangliosides inhibited melanoma growth at the primary site and metastat...

Full description

Saved in:
Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1989-03, Vol.81 (6), p.440-444
Main Authors: Iliopoulos, Dimitrios, Ernst, Carolyn, Steplewski, Zenon, Jambrosic, Jadranka A., Rodeck, Ulrich, Herlyn, Meenhard, Clark, Wallace H., Koprowski, Hilary, Herlyn, Dorothee
Format: Article
Language:English
Subjects:
Animal tumors. Experimental tumors
Animals
Antibodies, Monoclonal - therapeutic use
Biological and medical sciences
Cell Adhesion
Experimental skin tumors
Female
Gangliosides - immunology
Humans
Lung Neoplasms - pathology
Lung Neoplasms - secondary
Lymphatic Metastasis - pathology
Medical sciences
Melanoma, Experimental - pathology
Melanoma, Experimental - secondary
Melanoma, Experimental - therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Invasiveness
Neoplasm Transplantation
Transplantation, Heterologous
Tumors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A human melanoma variant cell line was obtained from a lung metastasis that arose spontaneously after we inoculated melanoma cells sc into a nude mouse. In this model, IGG2a monoclonal antibody (MAb) ME 36.1 defining the GD2/GD3 gangliosides inhibited melanoma growth at the primary site and metastatic spread of the cells, whereas an IGG1 variant of MAb ME 36.1 inhibited lung metastasis formation only. Possible mechanisms of antitumor effects of MAb ME 36.1 are discussed. [J Natl Cancer Inst 81:440–444, 1989]
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/81.6.440