Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas

Meningiomas represent a common class of tumors of the central nervous system. However, the molecular events underlying their formation are poorly understood. Because altered expression of the p53 tumor suppressor gene and the mdm2 proto-oncogene have been demonstrated in a wide variety of tumors, we...

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Bibliographic Details
Published in:Journal of neuro-oncology 1997-03, Vol.32 (1), p.39-44
Main Authors: PYKETT, M. J, LANDERS, J, GEORGE, D. L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blotting, Western
Brain cancer
Central nervous system
Gene Expression Regulation, Neoplastic - physiology
Genes, p53 - genetics
Humans
MDM2 protein
Medical sciences
Meningeal Neoplasms - genetics
Meningeal Neoplasms - metabolism
Meningioma
Meningioma - genetics
Meningioma - metabolism
Neurology
Nuclear Proteins
Oncogenes
p53 Protein
Proto-Oncogene Proteins - biosynthesis
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-mdm2
Proto-Oncogenes - genetics
Tumor Cells, Cultured
Tumor suppressor genes
Tumors
Tumors of the nervous system. Phacomatoses
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Summary:Meningiomas represent a common class of tumors of the central nervous system. However, the molecular events underlying their formation are poorly understood. Because altered expression of the p53 tumor suppressor gene and the mdm2 proto-oncogene have been demonstrated in a wide variety of tumors, we carried out studies to assess the possible involvement of these two genes in meningioma tumorigenesis. We used Western blot analysis to examine the level of expression of the mdm2 and p53 proteins in a series of sixteen primary meningiomas and four meningioma cell lines. The data obtained from these studies suggest that elevated expression of the p53 or mdm2 protein products does not represent a common event in the development of human meningiomas.
ISSN:0167-594X
1573-7373
DOI:10.1023/A:1005779406636