Recombination occurs during telomere formation in yeast

Short stretches of cloned telomeric sequences are necessary and sufficient for telomere formation in yeast as long as the sequences are present in the same orientation as they are found in vivo. During telomere formation, DNA termini usually undergo RAD52-independent recombination with other DNA ter...

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Bibliographic Details
Published in:Nature (London) 1989-02, Vol.337 (6206), p.429-433
Main Authors: Pluta, A.F, Zakian, V.A
Format: Article
Language:English
Subjects:
Animals
Chromosomes
Chromosomes - physiology
Cloning, Molecular
Deoxyribonucleic acid
DNA
DNA Replication
DNA Restriction Enzymes
DNA, Fungal - genetics
genetic recombination
Genetics
Medical research
Nucleic Acid Hybridization
Plasmids
Recombination, Genetic
replication
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
telocentrics
Tetrahymena - genetics
Transformation, Genetic
Yeasts
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Description
Summary:Short stretches of cloned telomeric sequences are necessary and sufficient for telomere formation in yeast as long as the sequences are present in the same orientation as they are found in vivo. During telomere formation, DNA termini usually undergo RAD52-independent recombination with other DNA termini as would be predicted by models of recombination-medicated telomere replication.
ISSN:0028-0836
1476-4687
DOI:10.1038/337429a0