TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 1997, Vol.6 (1), p.79-88
Main Authors: Bodmer, Jean-Luc, Burns, Kim, Schneider, Pascal, Hofmann, Kay, Steiner, Véronique, Thome, Margot, Bornand, Thierry, Hahne, Michael, Schröter, Michael, Becker, Karin, Wilson, Anne, French, Lars E., Browning, Jeffrey L., MacDonald, H.Robson, Tschopp, Jürg
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Apoptosis
Apoptosis Regulatory Proteins
Carrier Proteins - metabolism
Chromosomes, Human, Pair 1
Cytoplasm - chemistry
Fas Ligand Protein
Fas-Associated Death Domain Protein
Gene Expression
Humans
Ligands
Lymphocytes - physiology
Membrane Glycoproteins - metabolism
Molecular Sequence Data
Multigene Family
NF-kappa B - physiology
Receptors, Cell Surface - physiology
Receptors, Tumor Necrosis Factor - genetics
Receptors, Tumor Necrosis Factor - physiology
Receptors, Tumor Necrosis Factor, Member 25
RNA, Messenger - genetics
Sequence Alignment
Sequence Homology, Amino Acid
Signal Transduction
TNF-Related Apoptosis-Inducing Ligand
Tumor Necrosis Factor-alpha - metabolism
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Summary:A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis. Overexpression of TRAMP leads to two major responses, NF-κB activation and apoptosis. TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.
ISSN:1074-7613
1097-4180
DOI:10.1016/S1074-7613(00)80244-7