Novel Saponins Hainaneosides A and B Isolated from Marsdenia hainanensis

• Published in: Journal of natural products (Washington, D.C.) D.C.), 1997-02, Vol.60 (2), p.134-138
• Main Authors: Ma, Baoxia, Fang, Tianzheng, Ma, Kan, Ni, Jiahong, Wu, Houming, Ding, Wei-Pei, Jiang, Changsong
• Format: Article
• Language: English
• Subjects: Abortifacient Agents, Nonsteroidal - chemistry; Abortifacient Agents, Nonsteroidal - isolation & purification; Animals; ASCLEPIADACEAE; Biological and medical sciences; BRANCHE; BRANCHES; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; DRUG PLANTS; DRUGS; ESPECTROMETRIA; ESTRUCTURA QUIMICA; FERTILIDAD; FERTILITE; FERTILITY; General pharmacology; HAINAN; Magnetic Resonance Spectroscopy; Medical sciences; MEDICAMENT; MEDICAMENTOS; Oleanolic Acid - analogs & derivatives; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; PLANTAS MEDICINALES; PLANTE MEDICINALE; Plants - chemistry; RAMAS; Rats; SAPONINAS; SAPONINE; SAPONINS; Saponins - chemistry; Saponins - isolation & purification; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; Spectrometry, Mass, Fast Atom Bombardment; STEMS; STRUCTURE CHIMIQUE; TALLO; TIGE
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np960505w

Novel saponins possessing fertility-regulating activity, hainaneosides A (1) and B (2), have been isolated from the twigs and stems of Marsdenia hainanensis, and their structures have been elucidated unambiguously as 12-nicotinoyl sarcostin-3-O-β-d-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-d-allopyranosyl-(1→4)-β-d-oleandropyranosyl-(1→4)-β-d-cymaropyranosyl-(1→4)-β-d-cymaropyranoside and 12-nicotinoyl-20-cinnamoyl sarcostin-3-O-β-d-glucopyranosyl-(1→4)-3-O-methyl-6-deoxy-β-d-allopyranosyl-(1→4)-β-d-oleandropyranosyl-(1→4)-β-d-cymaropyranoside using NMR spectroscopic techniques and chemical transformations.